1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Chemical Properties

storage temp. 

−20°C

solubility 

DMF: > 20 mg/ml; DMSO: > 7 mg/ml; Ethanol: > 30 mg/ml; PBS (pH 7.2): > 250 μg/ml

form 

solution

color 

White to off-white

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-38-40-48/20/22-36/38-20/22-63

Safety Statements 

36/37-26

RIDADR 

UN 1888 6.1/PG 3

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Usage And Synthesis

Description

1,2-Dihexanoyl-sn-glycero-3-PC (DHPC-C6) is a synthetic phospholipid containing the short-chain (6:0) caproic acid inserted at the sn-1 and sn-2 positions. It is a substrate for phospholipase C isolated from B. cereus as well as phospholipase A₂ isolated from A. halys blomhoffi and N. naja atra snake venom. DHPC is commonly used in the generation of micelles, liposomes, and other types of artificial membranes.

Uses

L-α-Dihexanoyllecithin is used in the targeted delivery of adamantylated peptidoglycan immunomodulators in lipid nanocarriers.

Definition

ChEBI: 1,2-dihexanoyl-sn-glycero-3-phosphocholine is a phosphatidylcholine 12:0 in which both acyl groups are specified as hexanoyl. It has a role as a surfactant. It is functionally related to a hexanoic acid.

References

[1] LITTLE C. Phospholipase C from Bacillus cereus. Action on some artificial lecithins.[J]. Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1977, 31 4: 267-272. DOI: 10.3891/acta.chem.scand.31b-0267
[2] K TESHIMA. Role of Ca2+ in the substrate binding and catalytic functions of snake venom phospholipases A2.[J]. Journal of biochemistry, 1989, 106 3: 518-527. DOI: 10.1093/oxfordjournals.jbchem.a122885

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