AC2-12 Chemical Properties

storage temp. 

-20°C

form 

Solid

color 

White to off-white

Water Solubility 

Soluble to 1 mg/ml in 20% acetonitrile / Water

Sequence

Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-OH

AC2-12 Usage And Synthesis

Enzyme inhibitor

This annexin/lipocortin-1 peptidomimetic (FW = 1351.58 g/mol; Sequence: Acetyl-AMVSEFLKQAW; CAS 256447-08-2; Soluble to 1 mg/mL in 20% (vol/vol) acetonitrile-H2O) markedly reduces the degree of neutrophil adhesion and emigration across mouse mesenteric postcapillary venules, when administered at 13 mg/kg (s.c.), but does not modify cell rolling, when assessed directly by intravital microscopy. Ac2-12 also promotes neutrophil detachment from mesenteric endothelium after activation by intraperitoneal injection of 1 mg zymosan in mice (i.e., zymosan peritonitis). Ac2-12 phenocopies the effects observed in FormylatedPeptide Receptor (FPR) knock-out mice.

AC2-12(256447-08-2)Related Product Information

• H-LYS-SER-ASP-GLY-GLY-VAL-LYS-LYS-ARG-LYS-SER-SER-SER-SER-OH
• ASP-LEU-ASP-VAL-PRO-ILE-PRO-GLY-ARG-PHE-ASP-ARG-ARG-VAL-SER-VAL-ALA-ALA-GLU
• H-MET-HIS-ARG-GLN-GLU-ALA-VAL-ASP-CYS-LEU-LYS-LYS-PHE-ASN-ALA-ARG-ARG-LYS-LEU-LYS-GLY-ALA-OH
• CALP2
• CALMODULIN-DEPENDENT PROTEIN KINASE II (281-309)
• ITSFEEAKGLDRINERMPPRRDAMP
• ANGIOGENIN (108-122)
• AC2-26
• AC2-12