ITSFEEAKGLDRINERMPPRRDAMP Chemical Properties

storage temp. 

−20°C

form 

Lyophilized solid.

color 

White to off-white

Water Solubility 

Soluble to 1 mg/ml in water

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

ITSFEEAKGLDRINERMPPRRDAMP Usage And Synthesis

Uses

Calcineurin autoinhibitory peptide is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death[1][2].

References

[1] Hashimoto Y, et, al. Identification of an autoinhibitory domain in calcineurin. J Biol Chem. 1990 Feb 5; 265(4): 1924-7. PMID:2153670
[2] Terada H, et, al. Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide. J Neurochem. 2003 Dec; 87(5): 1145-51. DOI:10.1046/j.1471-4159.2003.02098.x

ITSFEEAKGLDRINERMPPRRDAMP(148067-21-4)Related Product Information

• AC2-12
• H-LYS-SER-ASP-GLY-GLY-VAL-LYS-LYS-ARG-LYS-SER-SER-SER-SER-OH
• ASP-LEU-ASP-VAL-PRO-ILE-PRO-GLY-ARG-PHE-ASP-ARG-ARG-VAL-SER-VAL-ALA-ALA-GLU
• H-MET-HIS-ARG-GLN-GLU-ALA-VAL-ASP-CYS-LEU-LYS-LYS-PHE-ASN-ALA-ARG-ARG-LYS-LEU-LYS-GLY-ALA-OH
• AC2-26
• CALP2
• CALMODULIN-DEPENDENT PROTEIN KINASE II (281-309)
• LCAT
• CALCINEURIN
• H-ARG-MET-NH2 ACETATE SALT
• ITSFEEAKGLDRINERMPPRRDAMP
• H-MET-PRO-OH
• H-MET-ALA-OH FORMATE
• H-GLY-MET-GLY-OH