CALP2 Chemical Properties

Boiling point:

1602.4±65.0 °C(Predicted)

Density 

1.205±0.06 g/cm3(Predicted)

storage temp. 

Desiccate at -20°C

solubility 

Soluble to 0.50 mg/ml in 10% ethanol / water

form 

Powder

pka

3.50±0.10(Predicted)

Sequence

Val-Lys-Phe-Gly-Val-Gly-Phe-Lys-Val-Met-Val-Phe

CALP2 Usage And Synthesis

Uses

CALP2 is a calmodulin (CaM) antagonist ( (Kd of 7.9 μM)) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages[1][2][3][4].

References

[1] R Houtman, et al. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J Immunol. 2001 Jan 15;166(2):861-7. DOI:10.4049/jimmunol.166.2.861
[2] R Ten Broeke, et al. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 2001 Aug;15(10):1831-3. DOI:10.1096/fj.01-0018fje
[3] Robert Ten Broeke, et al. Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab Invest. 2004 Jan;84(1):29-40. DOI:10.1038/sj.labinvest.3700002
[4] M Villain, et al. De novo design of peptides targeted to the EF hands of calmodulin. J Biol Chem. 2000 Jan 28;275(4):2676-85. DOI:10.1074/jbc.275.4.2676

CALP2(261969-04-4)Related Product Information

• AC2-12
• H-LYS-SER-ASP-GLY-GLY-VAL-LYS-LYS-ARG-LYS-SER-SER-SER-SER-OH
• ASP-LEU-ASP-VAL-PRO-ILE-PRO-GLY-ARG-PHE-ASP-ARG-ARG-VAL-SER-VAL-ALA-ALA-GLU
• H-MET-HIS-ARG-GLN-GLU-ALA-VAL-ASP-CYS-LEU-LYS-LYS-PHE-ASN-ALA-ARG-ARG-LYS-LEU-LYS-GLY-ALA-OH
• AC2-26
• CALMODULIN-DEPENDENT PROTEIN KINASE II (281-309)
• ITSFEEAKGLDRINERMPPRRDAMP
• CALP2