Ethyl 4'-hydroxy-3'-methoxycinnamate Chemical Properties

Melting point:

63-65 °C(lit.)

Boiling point:

164-166 °C0.5 mm Hg(lit.)

Density 

1.0643 (rough estimate)

refractive index 

1.4560 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Solid

pka

8.88±0.18(Predicted)

color 

White to Off-White

Sensitive 

Light Sensitive

BRN 

2696807

Stability:

Hygroscopic, Light Sensitive

InChIKey

ATJVZXXHKSYELS-FNORWQNLSA-N

CAS DataBase Reference

4046-02-0(CAS DataBase Reference)

NIST Chemistry Reference

ethyl ferulate(4046-02-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29189900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Ethyl 4'-hydroxy-3'-methoxycinnamate Usage And Synthesis

Description

Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid ethyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes. Ferulic acid ethyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC₅₀ = 66.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging). However, ferulic acid ethyl ester increases the expression of heme oxygenase-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide. Moreover, ferulic acid ethyl ester (25 μM) completely prevents cytotoxicity induced by ultraviolet B irradiation of normal human epidermal melanocytes, again associated with an induced expression of heme oxygenase-1 and Hsp70.

Uses

Ferulic acid ethyl ester is an ethyl ester derivative of Ferulic acid (F308900), which is used as an antioxidant and food preservative.

Ethyl 4'-hydroxy-3'-methoxycinnamate(4046-02-0)Related Product Information

• Ethyl acetate
• Ferulic Acid
• Cinnamic acid
• ISOXADIFEN-ETHYL
• Ethyl pyruvate
• Ethyl formate
• Sodium ferulic
• 2-Ethylhexyl ferulate
• Ethyl acrylate
• Octyl 4-methoxycinnamate
• Ethyl oleate
• Ethanol
• Ethyl glycolate
• Ethyl cinnamate
• Ethyl 4-methylcinnamate
• Ethyl cyanoacetate
• Ethylparaben
• 4-Hydroxycinnamic acid