Isoprocarb Chemical Properties

Melting point:

92.4°C

Boiling point:

329.46°C (rough estimate)

Density 

1.0945 (rough estimate)

refractive index 

1.5080 (estimate)

Flash point:

-18 °C

storage temp. 

Sealed in dry,2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Crystalline

pka

12.22±0.46(Predicted)

BRN 

1875020

CAS DataBase Reference

2631-40-5(CAS DataBase Reference)

NIST Chemistry Reference

2-(1-Methylethyl)phenyl methylcarbamate(2631-40-5)

EPA Substance Registry System

Isoprocarb (2631-40-5)

Safety Information

Hazard Codes 

Xn,N,F

Risk Statements 

22-50/53-67-65-38-11-20

Safety Statements 

60-61-62-33-16-9-25

RIDADR 

UN 3077 9/PG 3

WGK Germany 

3

RTECS 

FB7880000

HS Code 

29224999

Isoprocarb Usage And Synthesis

Description

Isoprocarb, o-cumenyl methylcarbamate (IUPAC), consists of colorless crystals, which are sparingly soluble in water and are readily soluble in acetone and methanol. Isoprocarb is produced by reaction of 2-isopropylphenol with methylisocyanate. Isoprocarb is used for control of rice, cacao, sugarcane, and vegetable pests.

Chemical Properties

Isoprocarb is a carbamate insecticide. It is a colourless crystalline substance, sparingly soluble in water (0.265g/l) and readily soluble in acetone(400g/l) and methanol (125g/l). It is hydrolysed in alkaline media.
The insecticide,with contact and stomach action, effectively controls leafhoppers,plant hoppers and aphids on a variety of crops like rice, cocoa, sugarcane and vegetables. Its residual activity gives effective pest control. It acts by inhibiting cholinesterase.

Uses

Isoprocarb is a non-systematic carbamate insecticide. Isoprocarb functions by reversibly inactivating the enzyme acetylcholinesterase in insects.

Definition

ChEBI: Isoprocarb is a carbamate ester. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a carbamate insecticide and an agrochemical. It is functionally related to a methylcarbamic acid and a 2-isopropylphenol.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by skin contact. When heated to decomposition it emits toxic fumes of NOx. See also CARBAMATES. Used for controlling leafhoppers, planthoppers, and bugs in rice and cacao.

Toxicology

The insecticide isoprocarb is a Class II toxin (moderately hazardous), with the acute oral LD50 among rats being 403-485mg/kg, while the percutaneous LD50 among male rats and mice is>500mg. It is a PAN Bad Actor chemical, since it is a cholinesterase inhibitor. Symptoms of poisoning with this insecticide include muscle weakness,dizziness,salivation,nausea,vomiting,sweating,headache,effects on the CNS and depression. PPE such as splash-resistant safety goggles and chemicalresistant clothing, gloves and masks are advised.

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