MAFP Chemical Properties

Boiling point:

455.3±34.0 °C(Predicted)

Density 

0.960±0.06 g/cm3(Predicted)

RTECS 

TA8108000

Flash point:

-16 °C

storage temp. 

-70°C

solubility 

DMF: 3 mg/ml; DMSO: 3 mg/ml; Ethanol: 3.5 mg/ml; Ethanol:PBS (pH 7.2) 1:1: .5 mg/ml; PBS (7.2): <1 mg/ml (colloidal suspension

form 

methyl acetate solution

Sensitive 

Air Sensitive

Safety Information

Hazard Codes 

F,Xi

Risk Statements 

11-36-66-67

Safety Statements 

16-26-29-33

RIDADR 

UN 1231 3/PG 2

WGK Germany 

1

MSDS

• Language:English Provider:SigmaAldrich

MAFP Usage And Synthesis

Uses

(all-Z)-5,8,11,14-Eicosatetraenylphosphonofluoridic Acid Methyl Ester, is a cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors.

Definition

ChEBI: Methyl Arachidonyl Fluorophosphonate is a phosphonic ester.

Biological Activity

Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH, anandamide amidase), the enzyme responsible for anandamide hydrolysis (IC 50 = 2.5 nM). Also binds irreversibly to CB 1 receptors (IC 50 = 20 nM).

Biochem/physiol Actions

MAFP is a selective, irreversible inhibitor of both calcium-dependent and calcium-independent cytosolic phospholipase A2, but not secretory phospholipase A2. MAFP is also a potent acetylcholinesterase inhibitor.

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