Lopinavir EP impurity Q Chemical Properties

Boiling point:

864.5±65.0 °C(Predicted)

Density 

1.154±0.06 g/cm3(Predicted)

storage temp. 

Refrigerator (0°C)

solubility 

Chloroform; Dichloromethane; DMSO; Ethyl Acetate; Methanol

pka

13.89±0.46(Predicted)

form 

Solid

color 

White

Lopinavir EP impurity Q Usage And Synthesis

Uses

N,N''-2-Hydroxy-1,4-bis(phenylmethyl)-2,6-dimethylphenoxy)acetamide is a by-product from the synthesis of (αS)-3-[2-(2,6-Dimethylphenoxy)acetyl]-N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide (Lopinavir EP Impurity R) (D476505), an impurity of Lopinavir (L469480), a selective HIV protease inhibitor.

Lopinavir EP impurity Q(667904-94-1)Related Product Information

• N-[(1S,2S,4S)-4-amino-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-2-(2,6-dimethylphenoxy)acetamide
• Lopinavir
• (S)-N-[(2S,4S,5S)-5-Amino-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
• (2,6-Xylyloxy)acetyl Lopinavir
• (αS)-3-[2-(2,6-DiMethylphenoxy)acetyl]-N-[(1S,3S,4S)-4-[[2-(2,6-diMethylphenoxy)acetyl]aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]tetrahydro-α-(1-Methylethyl)-2-oxo-1(2H)-pyriMidineacetaMide
• Lopinavir EP impurity P
• Lopinavir EP impurity K
• (2S)-N-[(2S,4R,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
• Lopinavir Impurity 3
• Lopinavir Impurity 7
• Lopinavir Impurity 16
• Lopinavir Impurity 2
• Lopinavir Impurity 8
• Lopinavir Impurity 13
• Lopinavir Impurity 4
• Lopinavir Impurity 12
• Lopinavir Impurity 20
• Lopinavir Impurity 9