alpha-Lobeline hydrochloride Chemical Properties

Melting point:

183-185 °C (dec.)(lit.)

alpha 

D20 -43° (c = 2)

refractive index 

-57.5 ° (C=1, H2O)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

H₂O: 25 mg/mL

form 

powder

color 

white to off-white

optical activity

[α]20/D 56.8°, c = 2 in H2O

Merck 

14,5551

BRN 

3920196

LogP

3.610 (est)

CAS DataBase Reference

134-63-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

Risk Statements 

23/25

Safety Statements 

36/37/39-45

RIDADR 

UN 1544 6.1/PG 3

WGK Germany 

3

RTECS 

OJ8490100

F 

8

HazardClass 

6.1(b)

PackingGroup 

III

MSDS

• Language:English Provider:SigmaAldrich

alpha-Lobeline hydrochloride Usage And Synthesis

Description

(–)-Lobeline is an alkaloid that has been found in Lobelia and has diverse biological activities. It binds to nicotinic acetylcholine receptors (nAChRs) in rat brain homogenates (K_i = 4 nM) and has antinociceptive effects in the tail-flick assay in mice. (–)-Lobeline (0.3 and 0.9 mg/kg) reduces the number of errors in a repeated acquisition procedure in the radial arm maze in rats. It also decreases immobility time in the forced swim test and feeding latency in the novelty suppressed feeding test, indicating antidepressant-like activity, in mice when administered at doses of 1 and 4 mg/kg.

Chemical Properties

White to Off-White Solid

Uses

A neuronal nicotinic acetylcholine receptor agonist. A respiratory stimulant

Uses

A neuronal nicotinic acetylcholine receptor agonist. A CNS stimulant.

Biological Activity

High affinity nicotinic receptor ligand, with a K i value of 4.4 nM in rat brain.

in vitro

clastogenicity of lobeline and possible interactions between lobeline and ethyl alcohol were investigated in a mutagen-sensitivity assay on cultures of human lymphoblastoid cell lines. lobeline alone was not clastogenic, but there was a marked increase in genetic damage resulting from a coclastogenic interaction between lobeline and ethyl alcohol. [5]

in vivo

male c57bl/6j mice were individually housed and acclimatized to 10% alcohol. lobeline is a partial nicotinic agonist that attenuates alcohol consumption and preference in male c57bl/6j mice. [3] cf-1 male mice received an intraperitoneal injection of lobeline (5 or 10mg/kg). lobeline did not show genotoxic or mutagenic effects and did not increase the ethanol-induced genotoxic effects in blood. lobeline also protected blood cells against oxidative damage induced by hydrogen peroxide. [4]

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