OXONIC ACID POTASSIUM SALT
OXONIC ACID POTASSIUM SALT Basic information
- Product Name:
- OXONIC ACID POTASSIUM SALT
- Synonyms:
-
- 1,4,5,6-tetrahydro-4,6-dioxo-s-triazine-2-carboxylicacid,potassiumsalt
- 5-azaoroticacid,potassiumsalt
- 4,6-Dihydroxy-1,3,5-triazine-2-carboxylic acid potassium salt, Allantoxanic acid
- （OXO）Oteracil potassium
- Potassium 4,6-dioxo-1H-1,3,5-triazine-2-carboxylate
- Potassium s-triazine-2,4-dione-6-carboxylate
- 1,4,5,6-Tetrahydro-4,6-dioxo-1,3,5-triazine-2-carboxylic acid potassium salt
- Allantoxanic acid potassium
- CAS:
- 2207-75-2
- MF:
- C4H2KN3O4
- MW:
- 195.17
- EINECS:
- 218-627-5
- Product Categories:
-
- Anti-cancer&immunity
- oncology
- Classes of Metal Compounds
- K (Potassium) Compounds (excluding simple potassium salts)
- Typical Metal Compounds
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Anticancer
- Mol File:
- 2207-75-2.mol
OXONIC ACID POTASSIUM SALT Chemical Properties
- Melting point:
- 300 °C(lit.)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Aqueous Base (Slightly), Water (Slightly, Heated, Sonicated)
- form
- Powder
- color
- White
- biological source
- rabbit
- Water Solubility
- Soluble in hot water.
- CAS DataBase Reference
- 2207-75-2(CAS DataBase Reference)
Safety Information
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- RR4580000
- HS Code
- 29349990
MSDS
- Language:English Provider:4,6-Dihydroxy-1,3,5-triazine-2-carboxylic acid potassium salt
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
OXONIC ACID POTASSIUM SALT Usage And Synthesis
Description
Oxonic acid is a uricase inhibitor that prevents metabolism and excretion of uric acid and induces embryotoxicity and nephrotoxicity in rats. It is a component of S-1, a mixture containing a prodrug of the antitumor agent 5-fluorouracil (5-FU; ), that suppresses the gastrointestinal toxicity of 5-FU without inhibiting its antitumor activity in rats. Formulations containing oxonic acid have been used to treat gastric, pancreatic, lung, head, neck, and breast carcinomas.
Chemical Properties
Off-White Solid
Uses
Antitumor effect potentiator and antitumor agent
Uses
Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.
Definition
ChEBI: Potassium 2,6-dihydroxytriazinecarboxylate is an organic molecular entity.
in vivo
Potassium oxonate can be used in animal modeling to create hyperuricemia models. After metabolism, Potassium oxonate primarily distributes within the cells of the small intestine. In the gastrointestinal tract, Potassium oxonate is converted to cyanuric acid via two pathways: the first involves direct conversion by gut microbiota in the cecum, and the second involves conversion through xanthine oxidase, or after degradation by stomach acid into 5-aza-uracil (5-AZU), followed by conversion through aldehyde oxidase[3].
Administration: 300 mg/kg ? i.p. ? once daily for 14 days
(2) On day 15, the mice are fasted for 12 hours, anesthetized with pentobarbital sodium, and then all sacrificed.
(3) Collect mouse blood samples in 2mL EP tubes, centrifuge (3000rpm, 4°C, 10min), and then store at -80°C for biochemical determination.
(4) The kidney tissue is quickly removed, weighed and divided into two parts, one part was fixed in 4% paraformaldehyde for histopathological examination, and the other part is stored at -80°C for further biochemical determination.
Histological changes: Inconspicuous boundaries between adjacent proximal tubule cells, swelling and proximal tubule necrosis.
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