ChemicalBook > CAS DataBase List > OXONIC ACID POTASSIUM SALT
OXONIC ACID POTASSIUM SALT
- Product Name
- OXONIC ACID POTASSIUM SALT
- CAS No.
- 2207-75-2
- Chemical Name
- OXONIC ACID POTASSIUM SALT
- Synonyms
- OXO;OTERACIL POTASSIUM;NOX4;POTASSIUM OXONATE;Potassium otastat;oxonic acid potassium;kox;KOX-1;Anti-KOX-1;otassiuM oxonate
- CBNumber
- CB9435346
- Molecular Formula
- C4H2KN3O4
- Formula Weight
- 195.17
- MOL File
- 2207-75-2.mol
More
Less
OXONIC ACID POTASSIUM SALT Property
- Melting point:
- 300 °C(lit.)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Aqueous Base (Slightly), Water (Slightly, Heated, Sonicated)
- form
- Powder
- color
- White
- biological source
- rabbit
- Water Solubility
- Soluble in hot water.
- CAS DataBase Reference
- 2207-75-2(CAS DataBase Reference)
More
Less
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- RR4580000
- HS Code
- 29349990
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 156124
- Product name
- Oxonic acid potassium salt
- Purity
- 97%
- Packaging
- 5g
- Price
- $44
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 156124
- Product name
- Oxonic acid potassium salt
- Purity
- 97%
- Packaging
- 25g
- Price
- $212
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SAB5700950
- Product name
- Anti- NOX4 antibody produced in rabbit
- Packaging
- 100UL
- Price
- $389
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- HPA015475
- Product name
- Anti-NOX4 antibody produced in rabbit
- Purity
- Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
- Packaging
- 25μL
- Price
- $282
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- HPA015475
- Product name
- Anti-NOX4 antibody produced in rabbit
- Purity
- Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
- Packaging
- 100μL
- Price
- $547
- Updated
- 2023/06/20
More
Less
OXONIC ACID POTASSIUM SALT Chemical Properties,Usage,Production
Description
Oxonic acid is a uricase inhibitor that prevents metabolism and excretion of uric acid and induces embryotoxicity and nephrotoxicity in rats. It is a component of S-1, a mixture containing a prodrug of the antitumor agent 5-fluorouracil (5-FU; ), that suppresses the gastrointestinal toxicity of 5-FU without inhibiting its antitumor activity in rats. Formulations containing oxonic acid have been used to treat gastric, pancreatic, lung, head, neck, and breast carcinomas.
Chemical Properties
Off-White Solid
Uses
Antitumor effect potentiator and antitumor agent
Uses
Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.
Definition
ChEBI: Potassium 2,6-dihydroxytriazinecarboxylate is an organic molecular entity.
in vivo
Potassium oxonate can be used in animal modeling to create hyperuricemia models. After metabolism, Potassium oxonate primarily distributes within the cells of the small intestine. In the gastrointestinal tract, Potassium oxonate is converted to cyanuric acid via two pathways: the first involves direct conversion by gut microbiota in the cecum, and the second involves conversion through xanthine oxidase, or after degradation by stomach acid into 5-aza-uracil (5-AZU), followed by conversion through aldehyde oxidase[3].
Induction of High Uric Acid[4]
Background
Potassium oxonate is a selective competitive uricase inhibitor that blocks the action of hepatic uricase.
Specific Modeling Methods
Mice : Kunming ? male ? 18-22 g
Administration: 300 mg/kg ? i.p. ? once daily for 14 days
Administration: 300 mg/kg ? i.p. ? once daily for 14 days
Note
(1) The animals are adapted to the environment for 1 week before the experiment. All animals have access to a standard diet and water ad libitum and are acclimated to specific pathogen-free (SPF) conditions of 22 ± 2 °C, 60 ± 5% humidity, and a fixed 12-h artificial light period.
(2) On day 15, the mice are fasted for 12 hours, anesthetized with pentobarbital sodium, and then all sacrificed.
(3) Collect mouse blood samples in 2mL EP tubes, centrifuge (3000rpm, 4°C, 10min), and then store at -80°C for biochemical determination.
(4) The kidney tissue is quickly removed, weighed and divided into two parts, one part was fixed in 4% paraformaldehyde for histopathological examination, and the other part is stored at -80°C for further biochemical determination.
(2) On day 15, the mice are fasted for 12 hours, anesthetized with pentobarbital sodium, and then all sacrificed.
(3) Collect mouse blood samples in 2mL EP tubes, centrifuge (3000rpm, 4°C, 10min), and then store at -80°C for biochemical determination.
(4) The kidney tissue is quickly removed, weighed and divided into two parts, one part was fixed in 4% paraformaldehyde for histopathological examination, and the other part is stored at -80°C for further biochemical determination.
Modeling Indicators
Molecular changes: Increased the levels of CRE, BUN, MDA, XOD and UA.
Reduced the levels of SOD and GSH-Px in serum.
Increased the levels of IL-1β and IL-18 in both serum and kidney and the mRNA expressions of IL-1β, NLRP3, ASC and caspase1.
Histological changes: Inconspicuous boundaries between adjacent proximal tubule cells, swelling and proximal tubule necrosis.
Histological changes: Inconspicuous boundaries between adjacent proximal tubule cells, swelling and proximal tubule necrosis.
Correlated Product(s): Hypoxanthine (HY-N0091)
Opposite Product(s): Curcumin (HY-N0005)
OXONIC ACID POTASSIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
OXONIC ACID POTASSIUM SALT Suppliers
- Tel
- 531-82812892
- Fax
- 0531-82812892
- sunshinepharm0531@163.com
- Country
- China
- ProdList
- 18
- Advantage
- 58
- Tel
- 0531-88658009 15552873609
- Fax
- 0531-88956078
- lxxcs@163.com
- Country
- China
- ProdList
- 96
- Advantage
- 58
- Tel
- 0531-88996911 15628983711
- Fax
- 0531-88996911
- 3305202763@qq.com
- Country
- China
- ProdList
- 125
- Advantage
- 58
- Tel
- 027-81302411 15377658509
- zs@dkybpc.com
- Country
- China
- ProdList
- 2236
- Advantage
- 58
- Tel
- +86-0531-88803416 13153166250
- Fax
- 0531-88803416
- sales@chemedpharma.com
- Country
- China
- ProdList
- 209
- Advantage
- 58
- Tel
- 0531-69954981 15666777973
- sales@hanyuchem.com
- Country
- China
- ProdList
- 49
- Advantage
- 58
- Tel
- 021-50182298 021-50180596
- Fax
- +86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2208
- Advantage
- 55
- Tel
- 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- sales@jonln.com
- Country
- China
- ProdList
- 1995
- Advantage
- 65
More
Less
View Lastest Price from OXONIC ACID POTASSIUM SALT manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Oxonic acid potassium salt 2207-75-2
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 500kg
- Release date
- 2021-09-11
Shandong Xuhuang New material CoLTD
- Product
- Oteracil potassium 2207-75-2
- Price
- US $120.00/KG
- Min. Order
- 1KG
- Purity
- 99.99%
- Supply Ability
- 100KG
- Release date
- 2025-02-25
Shanghai Chinqesen Biotechnology Co., Ltd.
- Product
- OXONIC ACID POTASSIUM SALT 2207-75-2
- Price
- US $30.00-20.00/BOX
- Min. Order
- 1BOX
- Purity
- 99
- Supply Ability
- 20TONS
- Release date
- 2023-10-31
2207-75-2, OXONIC ACID POTASSIUM SALTRelated Search:
Potassium Acetate
RESMETHRIN
1,3,5-Triazine
DIOXOPROMETHAZINE HCL
Potassium sodium tartrate
Potassium lactate
1,2,3-Propanetricarboxylicacid,2-hydroxy-,potassiumsalt
Potassium chloride
Potassium iodide
Potassium iodate
Potassium persulfate
Potassium Citrate
Potassium sorbate
Hydrochlorothiazide
Potassium clavulanate
(S)-ropivacaine hydrochloride hydrate
Phosphorus oxybromide
Oxolinic acid-D5