CROCONAZOLE Chemical Properties

Melting point:

72-73℃

Boiling point:

501.5±60.0 °C(Predicted)

Density 

1.16

storage temp. 

2-8°C

pka

6.29±0.10(Predicted)

form 

Solid

color 

Light yellow to yellow

CROCONAZOLE Usage And Synthesis

Chemical Properties

Soluble in ethyl acetate. Melting point 72-73°C. Cloconazole Hydrochloride (Cloconazole Hydrochloride): C18H15ClN2O?HCl.[77174-66-4]. Crystallized in ethyl acetate and acetonitrile, melting point 148.5-150°C. Acute toxicity LD50 rat (mg/kg): 7000 subcutaneous, 2500 oral.

Uses

Cloconazole is an antifungal azole drug.

Definition

ChEBI: Croconazole is an imidazole antifungal drug, a conazole antifungal drug, a member of monochlorobenzenes and an aromatic ether.

Indications

Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts.

Antimicrobial activity

Broad-spectrum imidazole antimycotic with activity against almost all pathogenic fungi.

Side effects

Local irritations and allergic reactions after topical treatment may occur in rare cases and are mainly due to the galenic formulation.

Metabolic pathway

When male rabbits are administered croconazole by intravenous injection, as many as 16 metabolites are excreted in the urine and 13 metabolites are identified. The biotransformation reaction of croconazole includes ring hydroxylation, O-dechlorobenzylation, and the loss of the imidazole ring.

CROCONAZOLE(77175-51-0)Related Product Information

• 1-(1-2-HYDROXYPHENYL)ETHENYL)-1H-IMIDAZOLE
• 2-BENZYLOXYBENZYLAMINE
• CROCONAZOLE HYDROCHLORIDE
• CROCONAZOLE