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Antifungal Drugs

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Since the 20th century, people have successively developed effective anti-fungal drugs such as griseofulvin. Flucytosine had been first introduced in the 1960s and its anti-fungal spectrum is limited to Candida and Cryptococcus, and is only used in combination with amphotericin B (AmB). A new era of the antifungal treatment is the development of the azole drug which reduces the toxicity and improves the antifungal effectiveness. The first drug, clotrimazole, was used only for the treatment of candidiasis infection of local mucosal and skin; the second, miconazole, is currently used only locally. It is not until the mid of 1970s when ketoconazole has been successfully developed before oral administration become effective against deep fungal infection. Ketoconazole has broad anti-bacterial spectrum and reduced toxicity, being considered to be a revolution during the development of antifungal drugs. However, severe patients can’t subject to oral administration for absorption. Moreover, the poor central nervous system penetration capability and poor antifungal activity as well as severe liver toxicity are limiting its clinical use.

In the late 1980s, people had successively developed itraconazole and fluconazole with more remarkable improved antimicrobial spectrum and bioavailability. Their emergence marked a new era of antifungal therapy. Even so, there are still no drugs that are absolutely fungicidal. In recent years, with increasing number of resistant strains, coupled with the limitations of drug toxicity, the treatment against fungal infection is facing many challenges. Currently the relatively promising drugs are drugs inhibiting the membrane ergosterol synthesis and interfering with cell wall 0-glucan synthesis, such as fluconazole, itraconazole and ciliary eumycetin. In addition, those old drugs with strong antibacterial effect but large toxicity are also subjecting to continuous improvement. Combination of two or more drugs is also the direction of antifungal therapy.

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Structure:
Chemical Name:
Luliconazole
CAS:
187164-19-8
MF:
C14H9Cl2N3S2
Structure:
Chemical Name:
Voriconazole
CAS:
137234-62-9
MF:
C16H14F3N5O
Structure:
Chemical Name:
Spectinomycin dihydrochloride pentahydrate
CAS:
22189-32-8
MF:
C14H27ClN2O8
Structure:
Chemical Name:
Biapenem
CAS:
120410-24-4
MF:
C15H18N4O4S
Structure:
Chemical Name:
Torezolid
CAS:
856866-72-3
MF:
C17H15FN6O3
Structure:
Chemical Name:
Miconazole nitrate
CAS:
22832-87-7
MF:
C18H14Cl4N2O.HNO3
Structure:
Chemical Name:
Linezolid
CAS:
165800-03-3
MF:
C16H20FN3O4
Structure:
Chemical Name:
Nisin
CAS:
1414-45-5
MF:
C143H230N42O37S7
Structure:
Chemical Name:
Fluconazole
CAS:
86386-73-4
MF:
C13H12F2N6O
Structure:
Chemical Name:
BAFILOMYCIN A1
CAS:
88899-55-2
MF:
C35H58O9
Structure:
Chemical Name:
Amorolfine
CAS:
78613-35-1
MF:
C21H35NO
Structure:
Chemical Name:
5-Bromo-5-nitro-1,3-dioxane
CAS:
30007-47-7
MF:
C4H6BrNO4
Structure:
Chemical Name:
Itraconazole
CAS:
84625-61-6
MF:
C35H38Cl2N8O4
Structure:
Chemical Name:
Oxiconazole nitrate
CAS:
64211-46-7
MF:
C18H13Cl4N3O
Structure:
Chemical Name:
cefsulodin sodium salt
CAS:
52152-93-9
MF:
C22H19N4O8S2.Na
Structure:
Chemical Name:
Sertaconazole nitrate
CAS:
99592-32-2
MF:
C20H15Cl3N2OS
Structure:
Chemical Name:
5-Fluorocytosine
CAS:
2022-85-7
MF:
C4H4FN3O
Structure:
Chemical Name:
Dihydrostreptomycin sulfate
CAS:
5490-27-7
MF:
C21H43N7O16S
Structure:
Chemical Name:
Chlorphenesin
CAS:
104-29-0
MF:
C9H11ClO3
Structure:
Chemical Name:
SULCONAZOLE
CAS:
61318-90-9
MF:
C18H15Cl3N2S
Structure:
Chemical Name:
GRAMICIDIN
CAS:
1405-97-6
MF:
C99H140N20O17
Structure:
Chemical Name:
KP 103
CAS:
164650-44-6
MF:
C18H22F2N4O
Structure:
Chemical Name:
IMIPENEM
CAS:
85960-17-4
MF:
C16H25N2O5S.C12H18N4O4.Na
Structure:
Chemical Name:
Econazole nitrate
CAS:
24169-02-6
MF:
C18H16Cl3N3O4
Structure:
Chemical Name:
Butoconazole
CAS:
64872-76-0
MF:
C19H17Cl3N2S
Structure:
Chemical Name:
ANTIPAIN HYDROCHLORIDE DIHYDRATE
CAS:
37691-11-5
MF:
C27H44N10O6
Structure:
Chemical Name:
BAFILOMYCIN B1
CAS:
88899-56-3
MF:
C44H65NO13
Structure:
Chemical Name:
Tolnaftate
CAS:
2398-96-1
MF:
C19H17NOS
Structure:
Chemical Name:
Naftifine
CAS:
65472-88-0
MF:
C21H21N
Structure:
Chemical Name:
Lanoconazole
CAS:
101530-10-3
MF:
C14H10ClN3S2
Structure:
Chemical Name:
IONOMYCIN
CAS:
56092-81-0
MF:
C41H72O9
Structure:
Chemical Name:
Cloxacillin-13C4 SodiuM Salt
CAS:
642-78-4
MF:
C19H19ClN3NaO5S
Structure:
Chemical Name:
Terbinafine
CAS:
91161-71-6
MF:
C21H25N
Structure:
Chemical Name:
Ozenoxacin
CAS:
245765-41-7
MF:
C21H21N3O3
Structure:
Chemical Name:
Miconazole
CAS:
22916-47-8
MF:
C18H14Cl4N2O
Structure:
Chemical Name:
Octenidine
CAS:
71251-02-0
MF:
C36H62N4
Structure:
Chemical Name:
SAPERCONAZOLE
CAS:
110588-57-3
MF:
C35H38F2N8O4
Structure:
Chemical Name:
Tedizolid Phosphate
CAS:
856867-55-5
MF:
C17H16FN6O6P
Structure:
Chemical Name:
Clotrimazole
CAS:
23593-75-1
MF:
C22H17ClN2
Structure:
Chemical Name:
Ciclopirox
CAS:
29342-05-0
MF:
C12H17NO2
Structure:
Chemical Name:
Taurolidine
CAS:
19388-87-5
MF:
C7H16N4O4S2
Structure:
Chemical Name:
Heptanoic acid
CAS:
111-14-8
MF:
C7H14O2
Structure:
Chemical Name:
Bifonazole
CAS:
60628-96-8
MF:
C22H18N2
Structure:
Chemical Name:
Butanedioicacid,2-hydroxy-,compd.with7-[(3S,5S)-3-amino-5-methyl-1-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylicacid
CAS:
951163-60-3
MF:
C20H25N3O4.C4H6O5
Structure:
Chemical Name:
Butenafine hydrochloride
CAS:
101827-46-7
MF:
C23H27N.ClH
Structure:
Chemical Name:
Fenticonazole nitrate
CAS:
73151-29-8
MF:
C24H21Cl2N3O4S
Structure:
Chemical Name:
Sulfaquinoxaline sodium
CAS:
967-80-6
MF:
C14H13N4NaO2S
Structure:
Chemical Name:
Daptomycin
CAS:
103060-53-3
MF:
C72H101N17O26
Structure:
Chemical Name:
Ketoconazole
CAS:
65277-42-1
MF:
C26H28Cl2N4O4
Chemical Name:
PHLEOMYCIN
CAS:
11006-33-0
MF:
C55H86N20O21S2
Structure:
Chemical Name:
Oxytetracycline dihydrate
CAS:
6153-64-6
MF:
C22H26N2O10
Structure:
Chemical Name:
CROCONAZOLE
CAS:
77175-51-0
MF:
C18H15ClN2O
Structure:
Chemical Name:
Butoconazole nitrate
CAS:
64872-77-1
MF:
C19H18Cl3N3O3S
Structure:
Chemical Name:
Terbinafine Hydrochloride
CAS:
78628-80-5
MF:
C21H26ClN
Structure:
Chemical Name:
Selenium sulfide
CAS:
7446-34-6
MF:
SSe
Structure:
Chemical Name:
Isoconazole
CAS:
27523-40-6
MF:
C18H14Cl4N2O
Structure:
Chemical Name:
Zinc heptylate
MF:
C14H30O2Zn
Structure:
Chemical Name:
Hexetidine
CAS:
141-94-6
MF:
C21H45N3
Structure:
Chemical Name:
Butenafine
CAS:
101828-21-1
MF:
C23H27N
Structure:
Chemical Name:
Sertaconazole nitrate
CAS:
99592-39-9
MF:
C20H15Cl3N2OS.HNO3
Structure:
Chemical Name:
Zinoconazole hydrochloride
CAS:
80168-44-1
MF:
C15H11Cl3N4S.ClH
Structure:
Chemical Name:
CEPHALOSPORIN C ZINC SALT
CAS:
59143-60-1
MF:
C16H21N3O8S.Zn
Structure:
Chemical Name:
CHRYSOMYCIN A
CAS:
82196-88-1
MF:
C28H28O9
Structure:
Chemical Name:
Siccanin
CAS:
22733-60-4
MF:
C22H30O3
Structure:
Chemical Name:
2,4,6-TRIBROMO-3-METHYLPHENOL
CAS:
4619-74-3
MF:
C7H5Br3O
Structure:
Chemical Name:
CHRYSOMYCIN B
CAS:
83852-56-6
MF:
C27H28O9
Structure:
Chemical Name:
MICONAZOLE NITRATE
CAS:
75319-48-1
MF:
C18H15Cl4N3O4
Structure:
Chemical Name:
HALOPROGIN
CAS:
777-11-7
MF:
C9H4Cl3IO
Structure:
Chemical Name:
Fenticonazole
CAS:
72479-26-6
MF:
C24H20Cl2N2OS
Structure:
Chemical Name:
Selenium sulfide
CAS:
7488-56-4
MF:
S2Se
Structure:
Chemical Name:
POLY-L-HISTIDINE
CAS:
61857-39-4
MF:
C6H9N3O2
Structure:
Chemical Name:
GRAMICIDIN A
CAS:
11029-61-1
MF:
C99H140N20O17
Structure:
Chemical Name:
Econazole nitrate
CAS:
68797-31-9
MF:
C18H16Cl3N3O4
Structure:
Chemical Name:
Naftifine hydrochloride
CAS:
65473-14-5
MF:
C21H22ClN
Chemical Name:
SULCONAZOLE NITRATE FPC(CRM STANDARD)
Structure:
Chemical Name:
Lancovutide
CAS:
1391-36-2
MF:
C89H125N23O25S3
Structure:
Chemical Name:
Vagistat
CAS:
65899-73-2
MF:
C16H13Cl3N2OS
Structure:
Chemical Name:
Brodimoprim
CAS:
56518-41-3
MF:
C13H15BrN4O2
Structure:
Chemical Name:
Amorolfine
CAS:
67467-83-8
MF:
C21H35NO
Structure:
Chemical Name:
Selenium sulfide
CAS:
56093-45-9
MF:
H4SSe
Structure:
Chemical Name:
Econazole
CAS:
27220-47-9
MF:
C18H15Cl3N2O
Structure:
Chemical Name:
acrisorcin
CAS:
7527-91-5
MF:
C13H10N2.C12H18O2