Lancovutide
Lancovutide Basic information
- Product Name:
- Lancovutide
- Synonyms:
-
- 2-l-lysine-6-(3-aminoalanine)-10-l-phenylalanine-12-l-phenylalanine-ancoveni
- antibioticpa48009
- cyclic6-19)-imine
- leucopeptin
- DURAMYCIN
- duramycin from streptoverticillium*cinnamoneus
- lancovutide
- duramycin from streptoverticillium*ci·Namoneus
- CAS:
- 1391-36-2
- MF:
- C89H125N23O25S3
- MW:
- 2013.28
- Product Categories:
-
- A - KAntibiotics
- Antibacterial
- Antibiotics A to
- Antibiotics A-FAntibiotics
- Chemical Structure Class
- Interferes with Protein SynthesisAntibiotics
- Mechanism of Action
- Spectrum of Activity
- Tetracyclines
- Mol File:
- 1391-36-2.mol
Lancovutide Chemical Properties
- Melting point:
- 271-273 ºC
- Density
- 1.0238 (rough estimate)
- refractive index
- 1.6680 (estimate)
- storage temp.
- 2-8°C
- solubility
- 0.1 M HCl: soluble10mg/mL
- form
- powder
- pka
- 3.15±0.11(Predicted)
- color
- Off-White to Pale Yellow
- Sequence
- Cys-Lys-Gln-Cys-Cys-Ala-Phe-Gly-Pro-Phe-{Abu}-Phe-Val-Cys-Asp-Gly-Asn-{Abu}-Lys-NH2 (Disulfide bridge: Cys1-Abu18, Cys4-Cys14, Cys5-Abu11)
- Stability:
- Hygroscopic
- InChIKey
- BPIFGBWRBGTMHX-OHSSMEBINA-N
Lancovutide Usage And Synthesis
Uses
Duramycin is a chloride secretion enhancer in airway epithelium.
Synthesis
Duramycin is a natural product produced by certain bacteria that binds to phosphatidylethanolamine (PE). We report here the genes that are involved in duramycin biosynthesis, and we produced duramycin by expressing those genes in Escherichia coli. We show that duramycin analogs can also be produced.
in vivo
Evaluation of [68Ga]NODAGA-Duramycin as a positron emission tomography (PET) tracer of cell death for whole-body detection of chemotherapy-induced organ toxicity. Organ uptake is analyzed in untreated and doxorubicin, busulfan, and cisplatin-treated mice 2 h after intravenous injection of [68Ga]NODAGA-Duramycin. [68Ga]NODAGA-Duramycin PET/CT is successfully applied to non-invasively detect chemotherapy-induced organ toxicity with high sensitivity in mice[3].
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Lancovutide(1391-36-2)Related Product Information
- Spiramycin
- Doxycycline
- Minocycline hydrochloride
- Gentamicin
- Maduramycin ammonium
- Rapamycin
- Azithromycin
- Lincomycin
- Clindamycin
- Vancomycin
- DL-Isoserine
- 2-Hydroxy-4-amino butanoic acid
- (R)-Isoserine
- 3-[(3-AMINO-3-OXOPROPYL)THIO]PROPANAMIDE
- H-D-ALA-ALA-OH
- H-ALA-D-ALA-ALA-OH
- Lancovutide
- . BUTANAMIDE, N-ETHYL-3,4-DIHYDROXY-, (3S)-