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PHLEOMYCIN

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PHLEOMYCIN Basic information

Product Name:
PHLEOMYCIN
Synonyms:
  • hleoMycin froM streptoMyces verticillus
  • CL990-cin
  • nsc616586
  • phleomycincomplex
  • PHLEOMYCIN
  • PHLEOMYCIN (STREPTOMYCES VERTICILLUS)
  • ZEOCIN(TM)
  • phleomycin from streptomyces verticillus
CAS:
11006-33-0
MF:
C55H86N20O21S2
MW:
0
EINECS:
634-572-3
Product Categories:
  • antibiotic
  • Interferes with DNA SynthesisSpectrum of Activity
  • L - ZMore...Close...
  • Antibacterial
  • Antibiotics
  • Mechanism of Action
  • Antibiotics A to
  • Antibiotics by Application
  • Antibiotics N-SAntibiotics
  • Antineoplastic and Immunosuppressive AntibioticsAntibiotics
  • Chemical Structure Class
  • Genetic Marker SelectionAntibiotics
  • GlycopeptidesAntibiotics
Mol File:
Mol File
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PHLEOMYCIN Chemical Properties

Boiling point:
527.46°C (rough estimate)
Density 
1.3193 (rough estimate)
refractive index 
1.5600 (estimate)
storage temp. 
2-8°C
solubility 
H2O: 10 mg/mL, clear, blue
form 
powder
color 
light blue
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36
RIDADR 
2811
WGK Germany 
3
RTECS 
SY0525000
10
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29419059
Toxicity
dog,LD50,intravenous,2500ug/kg (2.5mg/kg),Toxicology and Applied Pharmacology. Vol. 14, Pg. 590, 1969.

MSDS

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PHLEOMYCIN Usage And Synthesis

Description

Phleomycin is a glycopeptide antibiotic from Streptomyces whose cytotoxic action results from its ability to cause DNA fragmentation. The ability of phleomycin to block mammalian cells from entering mitosis has made it useful in cancer therapy, most commonly in conjunction with other therapeutic modalities. Phleomycin is also used, in conjunction with a vector carrying the bleomycin resistance protein ble, as a selective agent in the transformation of yeast, plant cells, and mammalian cells.

Uses

Phleomycin is a metal-complexing DNA degrading antibiotic.

General Description

Phleomycin is a glycopeptide antibiotic and is a member of the bleomycin family.

Biochem/physiol Actions

Phleomycin can bind and intercalate with the DNA that leads to DNA strand breaks. It acts as an inhibitor of DNA replication.

in vitro

previous study found that the chromosomes could be cleaved into nucleosomes and degraded by phleomycin over significantly narrower dose ranges than by bleomycin. in addition, phleomycin also showed lower specificity for internucleosomal cleavage than bleomycin. moreover, it was found that the higher reactivity of phleomycin did not solely result from its higher rate of internucleosomal and intranucleosomal chromatin cleavage, since short phleomycin reactions always led to more extensive chromatin cleavage at low concentrations [1].

in vivo

a study of the in-vivo effects of phleomycin on meiosis of the mouse egg demonstrated a spectrum of damage to both first metaphase and second metaphase with polar body. the minimal effective dose in vivo of 2.5 μg/g of body weight could alter 28.3% of first metaphase figures and 50% of second metaphase cells [2].

References

[1] moore, c. w. internucleosomal cleavage and chromosomal degradation by bleomycin and phleomycin in yeast. cancer research 48(23), 6837-6843 (1988).
[2] jagiello gm. action of phleomycin on the meiosis of the mouse ovum. mutat res. 1968 sep-oct;6(2):289-95.

PHLEOMYCINSupplier

Dalian Meilun Biotech Co., Ltd. Gold
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0411-62910999 13889544652
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Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277
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ShangHai YuanYe Biotechnology Co., Ltd.
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021-61312847 13636370518
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T&W GROUP
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021-61551611 13296011611
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Beijing HuaMeiHuLiBiological Chemical
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010-56205725
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waley188@sohu.com