Vagistat Chemical Properties

Melting point:

79-81oC

Boiling point:

534.5±50.0 °C(Predicted)

Density 

1.3115 (rough estimate)

refractive index 

1.6000 (estimate)

RTECS 

NI4480000

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Very slightly soluble in water, very soluble in methylene chloride, freely soluble in alcohol.

form 

powder

pka

6.66±0.12(Predicted)

color 

white to off-white

CAS DataBase Reference

65899-73-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

HS Code 

2934990002

Vagistat Usage And Synthesis

Description

Tioconazole is an antifungal agent, closely related to miconazole. Tioconazole is effective in the topical treatment of superficial fungal infections and appears to be more potent than miconazole against Candida and Trichophyton species.

Chemical Properties

White powder EINECS: 265-973-8

Originator

Pfizer (United Kiugdom)

Uses

Potent inhibitor of cytochrome-P450

Uses

Tioconazole is an antifungal that is more active than Fluconazole (F421000) or Voriconazole (V760000) against Candida glabrata mutant strains. Antifungal (topical).

Uses

antithrombotic

Definition

ChEBI: A member of the class of imidazoles that comprises 2-(2,4-dichlorophenyl)ethylimidazole carrying an additional (2-chloro-3-thienyl)methoxy substituent at position 2.

Indications

Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. In addition, tioconazole is indicated for therapy of vulvovaginal mycoses caused by Candida species and Candida (Torulopsis) glabrata.

Manufacturing Process

A solution of 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol (1.5 g, 5.8 mmol) dissolved in dry tetrahydrofuran (10 ml) was added to a stirred suspension of sodium hydride (0.39 g, as 80% dispersion in oil, 16 mmol) in dry tetrahydrofuran (10 ml) and warmed to 70°C for 90 minutes. The mixture was cooled in ice and a solution of 2-chloro-3- chloromethylthiophene (8.8 mmol) in dry tetrahydrofuran was added. The mixture was heated at 70°C for 3 hours and allowed to stir at room temperature overnight. The solvent was removed under vacuum and the residue stirred with dry ether (200 ml). The ether solution was filtered through Celite and saturated with hydrogen chloride gas to precipitate an oil which was solidified by trituration with ether and ethyl acetate. The solid product was collected and recrystallized from a mixture of acetone and diisopropyl ether to give the product, melting point 168°C to 170°C.

brand name

TROSYL

Therapeutic Function

Antifungal

Antimicrobial activity

Tioconazole is a broad-spectrum imidazole antimycotic with activity against almost all species of pathogenic fungi.

Pharmacokinetics

Tioconazole is normally not absorbed after topical application to the skin [173]. On vaginal application of an ovulum containing 300 mg tioconazole, a serum concentration of 21 μg/mL was observed after 8 h.

Clinical Use

1-[2-[(2-chloro-3-thienyl)methoxy]2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole (Vagistat) is used for the treatment ofvulvovaginal candidiasis. A vaginal ointment containing6.5% of the free base is available. Tioconazole is more effectiveagainst Torulopsis glabrata than are other azoles.

Side effects

Local irritations such as itching, burning sensations, erythema, and dermatitis, and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.

Vagistat(65899-73-2)Related Product Information

• Tioconazole Related Compound A (25 mg) (1-[2,4-Dichloro-beta-[(3-thenyl)-oxy]phenethyl]imidazole hydrochloride)
• Tioconazole Related CoMpound B
• Tiotropium-D6 Bromide
• Morphine Sulfate
• MORPHINE SULFATE NARCOTIC ANALGESIC
• 4-Chlorophenethylamine
• 1-(2,4-DICHLORO-PHENYL)-ETHYLAMINE
• Vagistat
• 2-Chlorophenethylamine
• alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
• 2-Chloro-3-methylthiophene
• 3-Thienylmethanol
• 1-(2-Chlorophenyl)-1-ethanol
• 2,4-DICHLORO-ALPHA-METHYLBENZYL ALCOHOL
• MORPHINE SULPHATE - CONTROLLED DRUG (PERMIT REQUIRED)
• Thiophene
• Chlorine
• 2-HYDROXY-2-(2-CHLOROPHENYL)ETHYLAMINE HYDROCHLORIDE