Butenafine Chemical Properties

Melting point:

200-202 °C

Boiling point:

426.1±14.0 °C(Predicted)

Density 

1.032±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 63 mg/mL (198.44 mM);Ethanol: 63 mg/mL (198.44 mM)

pka

7.87±0.50(Predicted)

Water Solubility 

Water: Insoluble

LogP

6.770 (est)

CAS DataBase Reference

101828-21-1(CAS DataBase Reference)

Butenafine Usage And Synthesis

Uses

Butenafine (Mentax) is a synthetic benzylamine antifungal agent, related structurally and pharmacologically to terbinafine. It is thought to act by inhibiting the enzyme squalene 2,3-epoxidase, resulting in decreased ergosterol and corresponding increase in squalene, with subsequent cell membrane permeability alteration and cell death. It is active against dermatophytes, yeast, and Sporothrix.

Definition

ChEBI: Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in funga cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.

brand name

Lotrimin (Schering); Mentax (Mylan Bertek).

Butenafine(101828-21-1)Related Product Information

• Butenafine hydrochloride
• Florfenicol
• Nitric acid
• Clobetasol propionate
• Ciclopirox ethanolamine
• Tolnaftate
• Pranoprofen
• Bendazac L-lysine
• 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE
• Ketoconazole
• Fenticonazole nitrate
• Terbinafine Hydrochloride
• 1-NAPHTHALENEMETHYLAMINE
• Butenafine
• BENZYL-(4-ISOPROPYL-BENZYL)-AMINE
• BENZYL-(4-TERT-BUTYL-BENZYL)-AMINE
• AKOS 216-16
• AKOS 216-17