BTS Chemical Properties

Melting point:

115 °C

Boiling point:

419.1±48.0 °C(Predicted)

Density 

1.204±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Dichloromethane, Ethyl Acetate (Slightly)

pka

11.54±0.30(Predicted)

form 

White crystalline solid

color 

White to Off-White

Sensitive 

Light Sensitive

CAS DataBase Reference

1576-37-0(CAS DataBase Reference)

Safety Information

RTECS 

XT5490000

HS Code 

2935.90.9500

Toxicity

rat,LD,oral,> 500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 41, 1953.

BTS Usage And Synthesis

Description

BTS is an inhibitor of skeletal muscle myosin II ATPase activity that reduces the affinity of ADP-myosin for actin. It inhibits calcium-stimulated ATPase activity of rabbit muscle myosin subfragment 1 (S1) in an actin-independent manner with an IC₅₀ value of approximately 5 μM. It is selective for calcium-stimulated myosin II over human platelet myosin II, kinesin, pyruvate kinase, and lactate dehydrogenase at 100 μM. BTS (2 μM) inhibits the activity of skeletal muscle myosin, reversibly reducing the sliding velocity of heavy meromyosin in a gliding-filament assay. It inhibits isometric calcium-activated tension in isolated fast-twitch rabbit psoas muscle fibers (IC₅₀ = ~3 μM) but not in isolated slow-twitch rat trabeculae and papillary cardiac muscle. BTS is also an intermediate in the synthesis of sulfonamides.

Chemical Properties

White Solid

Uses

A potent inhibitor of skeletal muscle Ca2+-stimulated myosin S1 ATPase (IC50 approx. 5uM) activity. Reversible blocks the gliding motility. Also weakens myosin interaction with F-actin. Does not affect platelet myosin II

Uses

A potent inhibitor of calcium-stimulated myosin S1 ATPase

Definition

ChEBI: 4-methyl-N-(phenylmethyl)benzenesulfonamide is a sulfonamide.

Synthesis Reference(s)

The Journal of Organic Chemistry, 28, p. 592, 1963 DOI: 10.1021/jo01037a523

Biological Activity

Selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC 50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.

storage

Desiccate at RT

BTS(1576-37-0)Related Product Information

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• bts2727
• bts7
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• p-Toluenesulfonic acid
• 3-(4-METHOXY-PHENYL)-3-(TOLUENE-4-SULFONYLAMINO)-PROPIONIC ACID
• N-BENZOYL-4-METHYL-BENZENESULFONAMIDE
• N-BENZYL-N-NITROSO-P-TOLUENESULFONAMIDE