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SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE

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SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE Basic information

Product Name:
SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE
Synonyms:
  • [1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl-butyl]-dimethyl-amine hydrate hydrochloride
  • 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethyl-butan-1-amine hydrate hydrochloride
  • 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine hydrate hydrochloride
  • 1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate
  • Sibutramine Hydrochloride CIV (125 mg)
  • )-SibutraMine-d6 HCl H2O
  • 1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride
  • CyclobutaneMethanaMine,1-(4-chlorophenyl)-N,N-diMethyl-a-(2-Methylpropyl)-, hydrochloride, hydrate (1:1:1)
CAS:
125494-59-9
MF:
C17H29Cl2NO
MW:
334.32
EINECS:
603-075-3
Product Categories:
  • CRESTOR
  • Intermediates & Fine Chemicals
  • Anilines, Aromatic Amines and Nitro Compounds
  • Pharmaceuticals
Mol File:
125494-59-9.mol
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SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE Chemical Properties

Melting point:
193-195.5°C
Flash point:
9℃
storage temp. 
Room temp
solubility 
DMSO: >30mg/mL
form 
solid
color 
white
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Safety Information

Hazard Codes 
Xi,T,F
Risk Statements 
36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
22-24/25-36-26-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
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SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE Usage And Synthesis

Description

Sibutramine was introduced as Meridia in the US for the control of obesity, in conjunction with a reduced-calorie diet. Sibutramine can be prepared in four steps from 4-chlorobenzyl cyanide. Sibutramine acts as a serotonin and noradrenaline reuptake inhibitor ; in animal studies, it reduces energy intake by creating a satieted feeling and increases energy expenditure by enhancing thermogenesis. In a clinical study in obese patients treated with 10 or 15 mg of Sibutramine once-daily, meaningful weight loss was sustained for 12 months ; an additional study demonstrated a lack of abuse potential. An appreciable part of Sibutramine's effect would also be due to its 2N-mono and didesmethylmetabolites, which are very potent monoamine reuptake inhibitors themselves.

Chemical Properties

White Solid

Originator

Knoll (Germany)

Uses

A serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure

Uses

antiobesity agent;neurotransmitter reuptake inhibitor

Uses

antihyperlipidemic

brand name

Meridia (Abbott);Meridia, Reductil.

SIBUTRAMINE HYDROCHLORIDE MONOHYDRATESupplier

Henan Wasai Biological Technology Co. LTD Gold
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15690866151
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2582571190@QQ.COM
Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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sales@chemreagents.com
Shanghai Longsheng chemical Co.,Ltd.
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021-58099652-8005 13585536065
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bin.wu@shlschem.com
Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
MedChemexpress LLC
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021-58955995
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sales@medchemexpress.cn