SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE Chemical Properties

Melting point:

193-195.5°C

Flash point:

9℃

storage temp. 

Room temp

solubility 

DMSO: >30mg/mL

form 

solid

color 

white

Safety Information

Hazard Codes 

Xi,T,F

Risk Statements 

36/37/38-39/23/24/25-23/24/25-11

Safety Statements 

22-24/25-36-26-45-36/37-16-7

RIDADR 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

3

SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE Usage And Synthesis

Description

Sibutramine was introduced as Meridia in the US for the control of obesity, in conjunction with a reduced-calorie diet. Sibutramine can be prepared in four steps from 4-chlorobenzyl cyanide. Sibutramine acts as a serotonin and noradrenaline reuptake inhibitor ; in animal studies, it reduces energy intake by creating a satieted feeling and increases energy expenditure by enhancing thermogenesis. In a clinical study in obese patients treated with 10 or 15 mg of Sibutramine once-daily, meaningful weight loss was sustained for 12 months ; an additional study demonstrated a lack of abuse potential. An appreciable part of Sibutramine's effect would also be due to its 2N-mono and didesmethylmetabolites, which are very potent monoamine reuptake inhibitors themselves.

Chemical Properties

White Solid

Originator

Knoll (Germany)

Uses

A serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure

Uses

antiobesity agent;neurotransmitter reuptake inhibitor

Uses

antihyperlipidemic

brand name

Meridia (Abbott);Meridia, Reductil.

SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE(125494-59-9)Related Product Information

• Sibutramine hydrochloride
• BTS
• 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
• [1-(4-chlorophenyl)cyclobutyl]methanamine
• Sibutramine
• Cyclobutylmethylamine hydrochloride
• SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE
• (1-PHENYLCYCLOBUTYL)METHYLAMINE
• (+/-)-DIDESMETHYLSIBUTRAMINE
• N-MONODESMETHYL SIBUTRAMINE HCL