N6-(4-Trifluoromethylbenzyl)adenosine Chemical Properties

Melting point:

151-153 °C

Boiling point:

675.9±65.0 °C(Predicted)

Density 

1.70±0.1 g/cm3(Predicted)

pka

13.11±0.70(Predicted)

N6-(4-Trifluoromethylbenzyl)adenosine Usage And Synthesis

Uses

N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[2] Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. DOI:10.1016/j.drudis.2021.02.020

N6-(4-Trifluoromethylbenzyl)adenosine(722505-71-7)Related Product Information

• para-TOPOLIN RIBOSIDE(pTR)
• N6-(3-Trifluoromethylbenzyl)-2'-C-methyl adenosine
• N6-(4-Methoxybenzyl)-2'-C-methyl adenosine
• N6-(3-Methoxybenzyl)-2'-C-methyl adenosine
• N6-(3-Trifluoromethylbenzyl)adenosine
• N6-(3-Trifluoromethylbenzyl)-3'-deoxyadenosine