8-M-PDOT
8-M-PDOT Basic information
- Product Name:
- 8-M-PDOT
- Synonyms:
-
- 8-METHOXY-2-PROPIONAMIDOTETRALIN
- 8-M-PDOT
- AH 002
- 8 M PDOT,8MPDOT
- Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-
- CAS:
- 134865-70-6
- MF:
- C14H19NO2
- MW:
- 233.31
- Mol File:
- 134865-70-6.mol
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8-M-PDOT Chemical Properties
- Boiling point:
- 447.8±45.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble to 50 mM in ethanol and to 100 mM in DMSO
- form
- Powder
- pka
- 15.87±0.20(Predicted)
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8-M-PDOT Usage And Synthesis
Description
8-M-PDOT is a melatonin receptor 2 (MT2) agonist (Ki = 1.12 nM). It is 5.2-fold selective for MT2 over MT1 receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson''s disease.
Uses
AH 002 is a selective melatonin receptor agonist.
Biological Activity
Melatonin receptor agonist, 20-fold selective for the MT 2 (vs MT 1 ) subtype. At human recombinant MT 1 and MT 2 receptors, displays pK i values of 8.23 and 8.95 respectively.
8-M-PDOTSupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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- 821-50328103-801 18930552037
- 3bsc@sina.com
EMMX Biotechnology LLC
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- 888-539-0666
- info@emmx.com
Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
- info@efebio.com
TargetMol Chemicals Inc.
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- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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- 18818260767
- sales@chemegen.com