Amiloride hydrochloride dihydrate Chemical Properties

Melting point:

>240℃

RTECS 

UQ2275500

storage temp. 

Store at -20°C

solubility 

Slightly soluble in water and in anhydrous ethanol.

pka

8.7(at 25℃)

form 

Solid

color 

Off-white to yellow

Water Solubility 

Soluble in water at 50mg/ml

Safety Information

WGK Germany 

3

HazardClass 

6.1

HS Code 

2933995300

Amiloride hydrochloride dihydrate Usage And Synthesis

Chemical Properties

Pale yellow or greenish-yellow powder.

Uses

Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 ?M. Amiloride ? HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

Uses

Diuretic;Antialdosteron

Uses

An epithelial sodium channel blocker

Definition

ChEBI: A hydrate that is the dihydrate of amiloride hydrochloride.

brand name

Midamor (Merck).

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