Amiloride hydrochloride dihydrate
Amiloride hydrochloride dihydrate Basic information
- Product Name:
- Amiloride hydrochloride dihydrate
- Synonyms:
-
- Amiloride Hydrochloride(HCl 2H20)
- MK-870 hydrochloride dihydrate
- Modamide
- AMILORIDE HCL DIHYDRATE
- AMILORIDE HYDROCHLORIDE 2-HYDRATE
- Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride, dihydrate
- AMILORIDE HYDROCHLORIDE (500 MG)
- AMILORIDEHYDROCHLORIDE,USP
- CAS:
- 17440-83-4
- MF:
- C6H8ClN7O.HCl.2H2O
- MW:
- 302.12
- EINECS:
- 620-474-8
- Product Categories:
-
- MK-870
- Mol File:
- 17440-83-4.mol
Amiloride hydrochloride dihydrate Chemical Properties
- Melting point:
- >240℃
- RTECS
- UQ2275500
- storage temp.
- Store at -20°C
- solubility
- Slightly soluble in water and in anhydrous ethanol.
- pka
- 8.7(at 25℃)
- form
- Solid
- color
- Off-white to yellow
- Water Solubility
- Soluble in water at 50mg/ml
- InChI
- InChI=1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2
- InChIKey
- LTKVFMLMEYCWMK-UHFFFAOYSA-N
- SMILES
- C1(C(NC(N)=N)=O)=NC(Cl)=C(N)N=C1N.[H]Cl.[H]O[H].[H]O[H]
Amiloride hydrochloride dihydrate Usage And Synthesis
Chemical Properties
Pale yellow or greenish-yellow powder.
Uses
Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 ?M. Amiloride ? HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.
Uses
Diuretic;Antialdosteron
Uses
An epithelial sodium channel blocker
Definition
ChEBI: A hydrate that is the dihydrate of amiloride hydrochloride.
brand name
Midamor (Merck).
in vivo
Amiloride hydrochloride dihydrate is a potent epithelial sodium channels (ENaCs) blocker. Amiloride is highly concentrated in the plasma 15 to 30 minutes following the injections. 2 mg/kg dose of Amiloride hydrochloride dihydrate has no effect on blood pressure, heart rate, mesenteric vascular resistance, or hindquarters vascular resistance as compare to the baseline measurements (n=7). Over a 2 hour period, Amiloride hydrochloride dihydrate elicits negligible responses in arterial pressure (-1±1 mmHg) and heart rate (-10±6 bpm/min) as compare to baseline levels. Results show an Amiloride hydrochloride dihydrate dose-related response pattern for the c-Fos activation in the area postrema (AP). Even at the lowest dose of Amiloride hydrochloride dihydrate (0.1 mg/kg), the number of c-Fos labeled neurons in the AP is statistically different from the control rats at a p<0.01 level[1].
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