NH125 Chemical Properties

Melting point:

88.2-94.9 °C

storage temp. 

-20°C

solubility 

DMSO: 20 mg/mL

form 

solid

color 

white to off-white

InChI

1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1

InChIKey

RVWOHCBHAGBLLT-UHFFFAOYSA-M

SMILES

[I-].CCCCCCCCCCCCCCCC[n+]1ccn(Cc2ccccc2)c1C

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Storage Class

11 - Combustible Solids

NH125 Usage And Synthesis

Uses

NH125 is an inhibitor of multiple kinases. It kills methicillin-resistant Staphylococcus.

Biological Activity

Histidine protein kinase and eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC 50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Exhibits anticancer activity in a variety of malignant cell lines (IC 50 values are 0.7 - 4.8 μ M) and blocks G 1 /S cell cycle progression. Also is an effective antibacterial agent in vitro (IC 50 = 6.6 μ M) and in vivo .

Biochem/physiol Actions

NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase.

IC 50

CaMK III: 60 nM (IC₅₀)

storage

Desiccate at -20°C

References

[1]. arora, s., et al., identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. cancer res, 2003. 63(20): p. 6894-9.
[2]. cheng, y., et al., integrated regulation of autophagy and apoptosis by eef2k controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. autophagy, 2013. 9(2): p. 208-19.
[3]. usui, t., et al., eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation. am j physiol heart circ physiol, 2013. 305(5): p. h756-68.

NH125(278603-08-0)Related Product Information

• RAF265(CHIR-265)
• GSK1904529A
• (-)-Blebbistatin
• Imatinib mesylate
• BX-795
• TW-37
• NH125
• 1-DODECYLIMIDAZOLE
• 1-ETHYL-3-METHYLIMIDAZOLIUM IODIDE
• 1-DECYL-2-METHYLIMIDAZOLE
• 1-METHYL-3-PROPYLIMIDAZOLIUM IODIDE