ChemicalBook > CAS DataBase List > NH125

NH125

Product Name
NH125
CAS No.
278603-08-0
Chemical Name
NH125
Synonyms
NH125 ，S7436;NH125 USP/EP/BP;NH125, 10 mM in DMSO;EEF-2 KINASE INHIBITOR;NH 125, CaMK III inhibitor;eEF-2 Kinase Inhibitor, NH125;3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide;1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazoliumiodide;eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem;NH 125,Calmodulin-dependent protein kinases,NH-125,Calmodulin-dependent kinases,NH125,Inhibitor,Autophagy,inhibit,Fungal,Virus Protease,Bacterial,CaMK
CBNumber
CB9503988
Molecular Formula
C27H45N2.I
Formula Weight
524.567
MOL File
278603-08-0.mol
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NH125 Property

Melting point:
88.2-94.9 °C
storage temp. 
-20°C
solubility 
DMSO: 20 mg/mL
form 
solid
color 
white to off-white
InChI
1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1
InChIKey
RVWOHCBHAGBLLT-UHFFFAOYSA-M
SMILES
[I-].CCCCCCCCCCCCCCCC[n+]1ccn(Cc2ccccc2)c1C
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N2162
Product name
NH125
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$265.3
Updated
2025/07/31
Cayman Chemical
Product number
10011250
Product name
NH125
Purity
≥95%
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
10011250
Product name
NH125
Purity
≥95%
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
10011250
Product name
NH125
Purity
≥95%
Packaging
25mg
Price
$341
Updated
2024/03/01
Sigma-Aldrich
Product number
N2162
Product name
NH125
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$1630
Updated
2023/01/07
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NH125 Chemical Properties,Usage,Production

Uses

NH125 is an inhibitor of multiple kinases. It kills methicillin-resistant Staphylococcus.

Biological Activity

Histidine protein kinase and eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC 50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Exhibits anticancer activity in a variety of malignant cell lines (IC 50 values are 0.7 - 4.8 μ M) and blocks G 1 /S cell cycle progression. Also is an effective antibacterial agent in vitro (IC 50 = 6.6 μ M) and in vivo .

Biochem/physiol Actions

NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase.

IC 50

CaMK III: 60 nM (IC50)

storage

Desiccate at -20°C

References

[1]. arora, s., et al., identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. cancer res, 2003. 63(20): p. 6894-9.
[2]. cheng, y., et al., integrated regulation of autophagy and apoptosis by eef2k controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. autophagy, 2013. 9(2): p. 208-19.
[3]. usui, t., et al., eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation. am j physiol heart circ physiol, 2013. 305(5): p. h756-68.

NH125 Preparation Products And Raw materials

Raw materials

Preparation Products

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NH125 Suppliers

China 67 India 1 Switzerland 1 United Kingdom 1 United States 10 Global 80
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4720
Advantage
55
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
40000
Advantage
60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4797
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
9359
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58

278603-08-0, NH125Related Search:

RAF265(CHIR-265) GSK1904529A (-)-Blebbistatin Imatinib mesylate BX-795 TW-37 NH125 1-DODECYLIMIDAZOLE 1-ETHYL-3-METHYLIMIDAZOLIUM IODIDE 1-DECYL-2-METHYLIMIDAZOLE 1-METHYL-3-PROPYLIMIDAZOLIUM IODIDE

  • eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem
  • EEF-2 KINASE INHIBITOR
  • 1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazoliumiodide
  • eEF-2 Kinase Inhibitor, NH125
  • NH125 USP/EP/BP
  • 3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide
  • NH 125,Calmodulin-dependent protein kinases,NH-125,Calmodulin-dependent kinases,NH125,Inhibitor,Autophagy,inhibit,Fungal,Virus Protease,Bacterial,CaMK
  • NH 125, CaMK III inhibitor
  • NH125, 10 mM in DMSO
  • NH125 ，S7436
  • 278603-08-0
  • C27H45IN2
  • Inhibitors