NH125

ChemicalBook > CAS DataBase List > NH125

Product Name: NH125
CAS No.: 278603-08-0
Chemical Name: NH125
Synonyms: NH125 USP/EP/BP;EEF-2 KINASE INHIBITOR;eEF-2 Kinase Inhibitor, NH125;3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide;1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazoliumiodide;eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem;NH 125,Calmodulin-dependent protein kinases,NH-125,Calmodulin-dependent kinases,NH125,Inhibitor,Autophagy,inhibit,Fungal,Virus Protease,Bacterial,CaMK
CBNumber: CB9503988
Molecular Formula: C27H45N2.I
Formula Weight: 524.567
MOL File: 278603-08-0.mol

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NH125 Property

Melting point:: 88.2-94.9 °C
storage temp.: -20°C
solubility: DMSO: 20 mg/mL
form: solid
color: white to off-white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N2162
Product name: NH125
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $173.6
Updated: 2024/03/01

Cayman Chemical

Product number: 10011250
Product name: NH125
Purity: ≥95%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 10011250
Product name: NH125
Purity: ≥95%
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 10011250
Product name: NH125
Purity: ≥95%
Packaging: 25mg
Price: $341
Updated: 2024/03/01

Sigma-Aldrich

Product number: N2162
Product name: NH125
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $1630
Updated: 2023/01/07

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NH125 Chemical Properties,Usage,Production

Uses

NH125 is an inhibitor of multiple kinases. It kills methicillin-resistant Staphylococcus.

Biological Activity

Histidine protein kinase and eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC 50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Exhibits anticancer activity in a variety of malignant cell lines (IC 50 values are 0.7 - 4.8 μ M) and blocks G 1 /S cell cycle progression. Also is an effective antibacterial agent in vitro (IC 50 = 6.6 μ M) and in vivo .

Biochem/physiol Actions

NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase.

storage

Desiccate at -20°C

References

[1]. arora, s., et al., identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. cancer res, 2003. 63(20): p. 6894-9.
[2]. cheng, y., et al., integrated regulation of autophagy and apoptosis by eef2k controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. autophagy, 2013. 9(2): p. 208-19.
[3]. usui, t., et al., eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation. am j physiol heart circ physiol, 2013. 305(5): p. h756-68.

NH125 Preparation Products And Raw materials

Raw materials

Preparation Products

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278603-08-0, NH125Related Search:

RAF265(CHIR-265) GSK1904529A (-)-Blebbistatin Imatinib mesylate BX-795 TW-37 NH125 1-DODECYLIMIDAZOLE 1-ETHYL-3-METHYLIMIDAZOLIUM IODIDE 1-DECYL-2-METHYLIMIDAZOLE 1-METHYL-3-PROPYLIMIDAZOLIUM IODIDE

eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem

EEF-2 KINASE INHIBITOR

1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazoliumiodide

eEF-2 Kinase Inhibitor, NH125

NH125 USP/EP/BP

3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide

NH 125,Calmodulin-dependent protein kinases,NH-125,Calmodulin-dependent kinases,NH125,Inhibitor,Autophagy,inhibit,Fungal,Virus Protease,Bacterial,CaMK

278603-08-0

C27H45IN2

Inhibitors