LASP1 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human

Background

LASP1 is a cytoskeletal scaffold protein belonging to the LIM protein subfamily. LASP1 consists of an N-terminal LIM domain, followed by two nebulin repeats, and a C-terminal SH3 domain. The nebulin repeats interact with actin, while the SH3 domain interacts with palladin, suggesting LASP1 functions as an actin-binding protein, possibly in cytoskeletal organization. LASP1 has been shown to localize to focal adhesions, lamellipodia, and membrane ruffles and might be involved in membrane migration. Overexpression of LASP1 has been associated with metastatic cancers, such as breast and ovarian cancer. In these cases, membrane, cytoplasmic, and nuclear localization of LASP1 in the tumor cell has been reported, suggesting LASP1 involvement in membrane and nuclear signaling.

References

[1] Tomasetto, C. et al. (1995) FEBS Lett 373, 245-9.
[2] Grunewald, T.G. and Butt, E. (2008) Mol Cancer 7, 31.
[3] Schreiber, V. et al. (1998) Mol Med 4, 675-87.
[4] Chew, C.S. et al. (2002) J Cell Sci 115, 4787-99.
[5] Rachlin, A.S. and Otey, C.A. (2006) J Cell Sci 119, 995-1004.
[6] Chew, C.S. et al. (2000) J Cell Sci 113 ( Pt 11), 2035-45.
[7] Lin, Y.H. et al. (2004) J Cell Biol 165, 421-32.
[8] Grunewald, T.G. et al. (2007) Br J Cancer 96, 296-305.
[9] Frietsch, J.J. et al. (2010) Br J Cancer 102, 1645-1653.
[10] Traenka, C. et al. (2010) Cancer Res 70, 8003-8014.

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