2-Furanboronic acid pinacol ester Chemical Properties

Boiling point:

255.0±13.0 °C(Predicted)

Density 

1.03±0.1 g/cm3(Predicted)

refractive index 

1.473-1.475

storage temp. 

Inert atmosphere,2-8°C

Appearance

Colorless to light yellow Solid-Liquid Mixture

BRN 

9045028

CAS DataBase Reference

374790-93-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

22-36/37/38-25

Safety Statements 

24/25-37/39-26-45

HS Code 

29321900

MSDS

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2-Furanboronic acid pinacol ester Usage And Synthesis

Chemical Properties

Clear colorless to pale yellow liquid

Synthesis

The general procedure for the synthesis of 2-(2-furyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane from 2-bromofuran and isopropanol pinacol borate was as follows: at -78 °C, a hexane solution of n-butyllithium (n-BuLi, 1.6 M, 65 mL, 0.10 mol) was slowly added to a 2-bromofuran (11 g, 0.068 mol) tetrahydrofuran (THF, 200 mL) solution. The reaction mixture was stirred at 0 °C for 2 hours. Subsequently, the reaction mixture was slowly added to a solution of 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (13 g, 0.068 mol) in THF (150 mL) at the same temperature. The mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, a small amount of methanol was added to quench the reaction. The resulting solution was washed three times with water and the organic phase was dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using hexane as eluent to afford the target product 2-(2-furyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

References

[1] Polymer, 2012, vol. 53, # 20, p. 4380 - 4387

2-Furanboronic acid pinacol ester(374790-93-9)Related Product Information

• Pinacol
• Diethyl phthalate
• 2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate
• Furan
• Tris(trimethylsilyl)phosphate
• Bis(pinacolato)diboron
• 3-Furanboronic acid
• Pinacolborane
• 2-Furanboronic acid
• Methyl acrylate
• Propyleneglycol alginate
• 3-FURONITRILE
• (furan-3-yl)(phenyl)methanamine hydrochloride
• Carbamic acid, 3-furanyl-, 1,1-dimethylethyl ester (9CI)
• 2,3-Dihydro-2,2-dimethyl-7-benzofuranol
• Ethyl 3-furancarboxylate
• furo[3,2-b]pyridine
• 1-(3-FURYL)METHANAMINE HYDROCHLORIDE