Basic information Safety Supplier Related

GYKI 52466 HYDROCHLORIDE

Basic information Safety Supplier Related

GYKI 52466 HYDROCHLORIDE Basic information

Product Name:
GYKI 52466 HYDROCHLORIDE
Synonyms:
  • gyki52466
  • 4-(8-METHYL-9H-1,3-DIOXOLO[4,5-H][2,3]BENZODIAZEPIN-5-YL)-BENZENAMINE HYDROCHLORIDE
  • GYKI 52466 HYDROCHLORIDE
  • 4-(8-Methyl-(9H)-1,3-dioxolo[4.5-h][2.3]benzodiazepine-5-yl)benzenaminehydrochloride
  • GYKI52466HCl
  • 1-(4-Aminophenyl)-4-methyl-7,8-(methylenedioxy)-5H-2,3-benzodiazepine
  • 4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-5-yl)aniline
  • 1-(p-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
CAS:
102771-26-6
MF:
C17H16ClN3O2
MW:
329.78
Product Categories:
  • Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:
102771-26-6.mol
More
Less

GYKI 52466 HYDROCHLORIDE Chemical Properties

Boiling point:
472.8±45.0 °C(Predicted)
Density 
1.39
storage temp. 
Desiccate at RT
solubility 
DMSO: 0.39 mg/mL
form 
solid
pka
8.14±0.20(Predicted)
color 
yellow
More
Less

Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-26-36
WGK Germany 
3

MSDS

More
Less

GYKI 52466 HYDROCHLORIDE Usage And Synthesis

Uses

4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)benzenamine is a non-competitive AMPA receptor antagonist and was found to have therapeutic potential for cocaine addiction treatment.

Definition

ChEBI: GYKI 52466 is a benzodiazepine.

Biological Activity

Selective non-competitive AMPA receptor antagonist (IC 50 values are 10-20, ~ 450 and >> 50 μ M for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. Has anti-proliferative effects in transformed cells. Also available as part of the AMPA Receptor Tocriset™ . Also available as part of the Kainate Receptor Tocriset™ .

storage

room temperature (desiccate)

GYKI 52466 HYDROCHLORIDESupplier

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Email
info@adooq.com
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Email
info@tsbiochem.com
More
Less

GYKI 52466 HYDROCHLORIDE(102771-26-6)Related Product Information