GYKI 52466 HYDROCHLORIDE
GYKI 52466 HYDROCHLORIDE Basic information
- Product Name:
- GYKI 52466 HYDROCHLORIDE
- Synonyms:
-
- gyki52466
- 4-(8-METHYL-9H-1,3-DIOXOLO[4,5-H][2,3]BENZODIAZEPIN-5-YL)-BENZENAMINE HYDROCHLORIDE
- GYKI 52466 HYDROCHLORIDE
- 4-(8-Methyl-(9H)-1,3-dioxolo[4.5-h][2.3]benzodiazepine-5-yl)benzenaminehydrochloride
- GYKI52466HCl
- 1-(4-Aminophenyl)-4-methyl-7,8-(methylenedioxy)-5H-2,3-benzodiazepine
- 4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-5-yl)aniline
- 1-(p-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
- CAS:
- 102771-26-6
- MF:
- C17H16ClN3O2
- MW:
- 329.78
- Product Categories:
-
- Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File:
- 102771-26-6.mol
GYKI 52466 HYDROCHLORIDE Chemical Properties
- Boiling point:
- 472.8±45.0 °C(Predicted)
- Density
- 1.39
- storage temp.
- Desiccate at RT
- solubility
- DMSO: 0.39 mg/mL
- form
- solid
- pka
- 8.14±0.20(Predicted)
- color
- yellow
MSDS
- Language:English Provider:SigmaAldrich
GYKI 52466 HYDROCHLORIDE Usage And Synthesis
Uses
4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)benzenamine is a non-competitive AMPA receptor antagonist and was found to have therapeutic potential for cocaine addiction treatment.
Definition
ChEBI: GYKI 52466 is a benzodiazepine.
Biological Activity
Selective non-competitive AMPA receptor antagonist (IC 50 values are 10-20, ~ 450 and >> 50 μ M for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. Has anti-proliferative effects in transformed cells. Also available as part of the AMPA Receptor Tocriset™ . Also available as part of the Kainate Receptor Tocriset™ .
in vivo
GYKI 52466 (intraperitoneal injection; 1.76-13.2 mg/kg; once) treatment provides potent anticonvulsant protection against sound-induced seizures in DBA/2 mice[2].
| Animal Model: | Male and female DBA/2 mice tested for sound-induced seizure responses[2] |
| Dosage: | 1.76-13.2 mg/kg |
| Administration: | Intraperitoneal injection; 1.76-13.2 mg/kg; once |
| Result: | Observed Maximal anticonvulsant protection after the i.p. treatment (5-15 min ). |
IC 50
Kainate Receptor: 11 μM (IC50)
storage
room temperature (desiccate)
GYKI 52466 HYDROCHLORIDESupplier
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