Benzydamine Chemical Properties

Melting point:

167-170 °C

Boiling point:

bp0.05 160°

Density 

1.1106 (rough estimate)

refractive index 

1.5900 (estimate)

storage temp. 

Refrigerator

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Oil

pka

9.25±0.28(Predicted)

color 

Orange

CAS DataBase Reference

642-72-8(CAS DataBase Reference)

NIST Chemistry Reference

1-Propanamine, n,n-dimethyl-3-[[1-(phenylmethyl)-1h-indazol-3-yl]oxy]-(642-72-8)

Safety Information

Toxicity

LD50 orl-rat: 9500 mg/kg ARZNAD 22,711,72

Benzydamine Usage And Synthesis

Description

Benzydamine is an analytical reference standard categorized as an analgesic. Benzydamine has been abused and is associated with hallucinations, muscle weakness, and excitability. This product is intended for research and forensic applications.

Uses

Benzydamine is a nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties.

Uses

Analgesic; antipyretic; anti-inflammatory.

Definition

ChEBI: Benzydamine is a member of the class of indazoles carrying benzyl and 3-(dimethylamino)propyl groups at positions 1 and 3 respectively. A locally-acting nonsteroidal anti-inflammatory drug that also exhibits local anaesthetic and analgesic properties. It has a role as a central nervous system stimulant, a non-steroidal anti-inflammatory drug, a hallucinogen, a local anaesthetic and an analgesic. It is a member of indazoles, an aromatic ether and a tertiary amino compound. It is a conjugate base of a benzydamine(1+).

brand name

Tantum (Angelini Francesco, Italy).

Safety Profile

Poison by intraperitoneal andintravenous routes. Moderately toxic by ingestion andsubcutaneous routes. When heated to decomposition itemits toxic fumes of NOx.

References

[1] YUAN-SHIOU HUANG. The effectiveness of benzydamine hydrochloride spraying on the endotracheal tube cuff or oral mucosa for postoperative sore throat.[J]. Anesthesia and analgesia, 2010, 111 4: 887-891. DOI: 10.1213/ane.0b013e3181e6d82a
[2] JACEK SEIN ANAND  Roman P K  Magdalena Lukasik Glebocka. Recreational abuse with benzydamine hydrochloride (tantum rosa).[J]. Clinical Toxicology, 2007, 45 2: 198-199. DOI: 10.1080/15563650600981210

Benzydamine(642-72-8)Related Product Information

• Diethoxydimethylsilane
• 3-Dimethylaminopropylamine
• Benzyltriethylammonium chloride
• Benzyl alcohol
• Benzyl acetate
• Benzyltrimethylammonium chloride
• Propyl gallate
• Dimethyldimethoxysilane
• N,N-Dimethyl-1,4-phenylenediamine
• Benzyl chloride
• Benzydamine hydrochloride
• Phenylacetone
• Benzyl
• 3-Indazolinone
• 1-Benzyl-3-hydroxy-1H-indazole
• 1-BENZYL-3-METHOXY-1H-INDAZOLE
• BENZYDAMINE N-OXIDE HYDROGEN MALEATE
• 1-methylindazole