BENZTHIAZIDE
BENZTHIAZIDE Basic information
- Product Name:
- BENZTHIAZIDE
- Synonyms:
-
- 6-Chloro-3-[[(phenylMethyl)thio]Methyl]-2H-1,2,4-benzothiadiazine-7-sulfonaMide 1,1-Dioxide
- ((benzylthio)methyl)-3chloro-6dioxyde-1,1sulfonamide-7benzothiadiazine-1,2,
- -1,-dioxide
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-((benzylthio)methyl)-6-chloro-, 1,1-dioxide
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(((phenylmethyl)thio)methyl)-, dioxide
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide
- 2h-1,2,4-benzothiadiazine-7-sulfonamide,3-((benzylthio)menthyl)-6-chloro-,1,1
- 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(((phenylmethyl)thio)methyl
- CAS:
- 91-33-8
- MF:
- C15H14ClN3O4S3
- MW:
- 431.94
- EINECS:
- 202-061-0
- Product Categories:
-
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- AQUATAG
- Heterocyclic Compounds
- Building Blocks
- Chemical Synthesis
- Heterocyclic Building Blocks
- Others
- S-Containing
- Mol File:
- 91-33-8.mol
BENZTHIAZIDE Chemical Properties
- Melting point:
- 231-232° (U.S. patent); mp 238-239° (P'an)
- Boiling point:
- 680.6±65.0 °C(Predicted)
- Density
- 1.4176 (rough estimate)
- refractive index
- 1.6100 (estimate)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.57±0.20(Predicted)
- color
- White to Off-White
- Water Solubility
- 2.8mg/L(room temperature)
- EPA Substance Registry System
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide (91-33-8)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 42/43
- Safety Statements
- 26-36
- WGK Germany
- 2
- RTECS
- DK8400000
- Hazardous Substances Data
- 91-33-8(Hazardous Substances Data)
- Toxicity
- LD50 in mice, rats (mg/kg): >5000, >10000 orally; 410, 422 i.v. (P'an)
MSDS
- Language:English Provider:SigmaAldrich
BENZTHIAZIDE Usage And Synthesis
Originator
Exna,Robins,US,1960
Uses
Benzthiazide is a diuretic, antihypertensive agent.
Definition
ChEBI: 7-Sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by chlorine and that at position 3 is substituted by a benzylsulfanylmethyl group. A diuretic, it is used to treat hypertension and edema.
Manufacturing Process
The preparation of the dihydro analog is as follows:
(A) Preparation of 3-Chloromethyl-6-Chloro-7-Sulfamyl-3,4-DihydroBenzothiadizine-1,1-Dioxide - To 8 ml of 40-50% chloroacetaldehyde aqueous
solution and 7 ml of dimethylformamide are added 10 grams of 2,4-
disulfamyl-5-chloroaniline. The mixture is heated on a steam bath for 2 hours
after which it is concentrated at reduced pressure. The residue is triturated
with water. The solid material is recrystallized from methanol-ether after
treatment with activated carbon to give 7.2 grams of product, MP 229°-
230°C.
(B) Preparation of Benzylthiomethyl-6-Chloro-7-Sulfamyl-3,4-
Dihydrobenzothiadiazine-1,1-Dioxide - A mixture of 3-(chloromethyl)-6-chloro-
7-sulfamyl-3,4-dihydrobenzothiadiazine-1,1-dioxide (0.02 mol) and
benzylmercaptan (0.024 mol) in 20 ml of 10% sodium hydroxide and 20 ml of
dimethylformamide is stirred at room temperature for 6 hours. After heating
for 10 minutes on a steam bath, the mixture is cooled and acidified with 6 N
HCl. The product, after recrystallization from acetone, melts at 210°-211°C.
brand name
Aquatag (Solvay Pharmaceuticals); Fovane (Pfizer).
Therapeutic Function
Diuretic, Antihypertensive
Safety Profile
Poison by intravenous route. Adiuretic and antihypertensive agent. When heated todecomposition it emits very toxic fumes of SOx, NOx, andCl-.
BENZTHIAZIDESupplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 021-021-58432009 400-005-6266
- sales8178@energy-chemical.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 400 638 7771
- sales@heowns.com
- Tel
- 010-56205725
- waley188@sohu.com
BENZTHIAZIDE(91-33-8)Related Product Information
- Xylazine Hydrochloride
- hydrobentizide
- Xylazine
- Chlorothiazide
- 2-(BENZYLTHIO)ETHYLAMINE HYDROCHLORIDE
- 4-Chloro-N-methylbenzenesulphonamide
- 4-CHLORO-1,3-BENZENEDITHIOL
- CLOFENAMIDE
- 4-Amino-6-chlorobenzene-1,3-disulfonamide
- 2-METHYLSULFANYL-ACETAMIDINE
- 2-AMINO-N-METHYLBENZENESULFONAMIDE
- 2H-1,2,4-Benzothiadiazine 1,1-dioxide
- 2-Aminobenzenesulfonamide
- BENZTHIAZIDE