4-Amino-6-chlorobenzene-1,3-disulfonamide Chemical Properties

Melting point:

257-261 °C(lit.)

Boiling point:

614.4±65.0 °C(Predicted)

Density 

1.584 (estimate)

refractive index 

1.6100 (estimate)

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

9.24±0.60(Predicted)

form 

Powder

color 

White to off-white

Merck 

14,2076

BRN 

1083877

CAS DataBase Reference

121-30-2(CAS DataBase Reference)

EPA Substance Registry System

1,3-Benzenedisulfonamide, 4-amino-6-chloro- (121-30-2)

Safety Information

Hazard Codes 

T

Risk Statements 

23/24-33-20/21

Safety Statements 

28-36/37-36/37/39-26-22

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29350090

MSDS

• Language:English Provider:3-Chloro-4,6-disulfamoylaniline
• Language:English Provider:SigmaAldrich

4-Amino-6-chlorobenzene-1,3-disulfonamide Usage And Synthesis

Description

4-Amino-6-chlorobenzene-1,3-disulfonamide is obtained by treating the chloride with ammonia in tert-butanol and concentrating the solution by evaporation; the yield is 80 %. Condensation with formic acid gives 6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide, an important diuretic.

Chemical Properties

Light Brown Solid

Uses

Diuretic.

Uses

4-Amino-6-chloro-1,3-benzenedisulfonamide was used in the synthesis of deuterated thiazides by undergoing condensation with appropriately labeled aldehydes.

Definition

ChEBI: Chloraminophenamide is a sulfonamide.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

4-Amino-6-chlorobenzene-1,3-disulfonamide (121-30-2)Related Product Information

• Chlorothiazide
• 4-Chloroaniline
• Glycine
• 6-Aminocaproic acid
• 2,6-Dichloroaniline
• Chlorobenzene
• 3-Chloroaniline
• ALTRENOGEST
• 2-Chloroaniline
• Hydrochlorothiazide
• DL-Phenylalanine
• Tris(hydroxymethyl)aminomethane
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxode
• 3-Methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide
• 6,7-Dichloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
• 4-AMINO-6-CHLORO-BENZENE-1,3-DISULFONYL DICHLORIDE
• HYDROCHLOROTHIAZIDE-3,3-D2
• Hydrochlorothiazide-13C,d2