4-Cyclohexylphenol Chemical Properties

Melting point:

130-135°C

Boiling point:

213-215°C

Density 

0.9452 (rough estimate)

vapor pressure 

0.823-3.6Pa at 25℃

refractive index 

1.5415 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

form 

Solid:flakes

pka

10.15±0.13(Predicted)

color 

White to Light yellow to Light orange

Water Solubility 

66.66mg/L(25 ºC)

Dielectric constant

4.0（54℃）

LogP

4.22-4.33

CAS DataBase Reference

1131-60-8(CAS DataBase Reference)

NIST Chemistry Reference

Phenol, 4-cyclohexyl-(1131-60-8)

EPA Substance Registry System

Phenol, 4-cyclohexyl- (1131-60-8)

Safety Information

Hazard Codes 

Xi,N

Risk Statements 

20/21/22-36/37/38-50/53-41-37/38

Safety Statements 

26-36/37/39-61-60-39

Hazard Note 

Irritant

HS Code 

2907199090

MSDS

• Language:English Provider:4-Cyclohexylphenol

4-Cyclohexylphenol Usage And Synthesis

Uses

4-Cyclohexylphenol is a derivative of Cyclohexylphenol (CHP), which is widely used in the preparation of dyes, resins, and biocides^[2]. 4-Cyclohexylphenol labelled with 35s can be used for metabolic studies^[3].

Synthesis

4-Cyclohexylphenol is obtained by hydroalkylation of phenol using phenol as a raw material in the presence of a palladium catalyst and a molten salt (NaCl-AlCl3)^[1]. The specific synthesis steps are as follows:
The hydroalkylation of phenol in the presence of palladium catalyst and fused salt (NaCl-AlCl3) under hydrogen pressure was carried out. By using 1% Pd-Al2O3 (1 g) and the fused salt (1 : 1 mol ratio, 6 g), 4-cyclohexylphenol was obtained selectively from 1 (30 g) in a yield of 31.9% at 120°C for 4.5 h.

References

[1] T. KAMIYAMA; M. I; S Enomoto. Hydroalkylation of phenol to cyclohexylphenol in the presence of Pd-Al2O3 and NaCl-AlCl3 under hydrogen pressure.[J]. Chemical & pharmaceutical bulletin, 1986. DOI:10.1248/CPB.34.450.
[2] S. GUTIéRREZ-RUBIO . Synthesis of cyclohexylphenol via phenol hydroalkylation using Co2P/zeolite catalysts[J]. Catalysis Today, 2022. DOI:10.1016/j.cattod.2021.11.039.
[3] D.J. HEARSE; Gillian M P; A H Olavesen. The preparation and characterization of a series of 35S-labelled aryl sulphate esters for metabolic studies[J]. Biochemical pharmacology, 1969. DOI:10.1016/0006-2952(69)90022-7.

4-Cyclohexylphenol(1131-60-8)Related Product Information

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