4,4'-Cyclohexylidenebisphenol Chemical Properties

Melting point:

190-192 °C(lit.)

Boiling point:

371.51°C (rough estimate)

Density 

1.0496 (rough estimate)

refractive index 

1.5490 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

Water Solubility 

Practically insoluble in water

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

9.91±0.30(Predicted)

color 

White to Almost white

InChI

InChI=1S/C18H20O2/c19-16-8-4-14(5-9-16)18(12-2-1-3-13-18)15-6-10-17(20)11-7-15/h4-11,19-20H,1-3,12-13H2

InChIKey

SDDLEVPIDBLVHC-UHFFFAOYSA-N

SMILES

C1(C2=CC=C(O)C=C2)(C2=CC=C(O)C=C2)CCCCC1

CAS DataBase Reference

843-55-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

3077

WGK Germany 

3

HazardClass 

9

PackingGroup 

III

HS Code 

29072990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:SigmaAldrich

4,4'-Cyclohexylidenebisphenol Usage And Synthesis

Chemical Properties

White Crystal

Uses

Bisphenol Z is one of the many derivatives of Bisphenol A (B519495) that can be used as HIF (hypoxia-inducible factor) inhibitors, antitumor agents, angiogenesis inhibitors, and antihypoxic agents.

Definition

ChEBI: Bisphenol Z is a diarylmethane.

Synthesis

In a 500 mL four-necked flask equipped with a PTFE stirrer, thermometer, reflux condenser and HCl gas introduction tube, 150.4 g (16 mol) of phenol, 39.2 g (0.4 mol) of cyclohexanone, 100 mL of toluene, and 624 g (008 mol) of 2-mercaptoethanol were added; and +dried HCl gas was passed through the flask at a uniform rate of 016 mol/h. The reaction was heated to 30 ??C and maintained for 7 h. Stopping stirring and heating, the slurry was filtered under pressure to obtain a pink filter cake. The reaction was heated in a water bath, raised to 30 ??C and kept for 7 h. Stirring and heating were stopped and the resulting slurry-like consistency was filtered under reduced pressure to give a pink filter cake. The filter cake was washed with deionized water at 100 ?? for 3~4 times until the pH was 7, and the crude product was dried to obtain 114.5 g. The crude product was dissolved in a round bottom flask heated with anhydrous ethanol, and then filtered under reduced pressure while it was hot to filter off the impurities insoluble in ethanol, the filtrate was cooled to room temperature, and then put into a refrigerator to cool down for crystallization, and recrystallized for 2~3 times, and the white crystals of 105.5 g were obtained with the yield of 98.4%.

4,4'-Cyclohexylidenebisphenol(843-55-0)Related Product Information

• 9,9-Bis(4-hydroxyphenyl)fluorene
• Triclosan
• Butylated Hydroxytoluene
• Methylcyclohexane
• CYCLOHEXANE-D12
• Bisphenol A
• Bis(4-hydroxyphenyl) Sulfone
• tert-Butyl acrylate
• 4,4'-Sulphonylbis(2,6-dibromophenol)
• Tetrabromobisphenol A
• Cyclohexylbenzene
• Cyclohexane
• Cyclohexene oxide
• NITROCYCLOHEXANE
• Ethylcyclohexane
• 1,3-Dihydroxyacetone
• 4,4'-DIHYDROXYDIPHENYLMETHANE
• Chlorocyclohexane