MBP (85-99) peptide antagonist trifluoroacetate salt CAS#: 444305-16-2

MBP (85-99) peptide antagonist trifluoroacetate salt Basic information

Product Name:

MBP (85-99) peptide antagonist trifluoroacetate salt

Synonyms:

MBP (85-99) peptide antagonist trifluoroacetate salt
H-GLU-LYS-PRO-LYS-VAL-GLU-ALA-TYR-LYS-ALA-ALA-ALA-ALA-PRO-ALA-OH
(4S)-4-amino-5-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxyethyl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-5-oxopentanoic acid
MBP (85-99) peptide antagonist
Myelin Basic Protein (85-99) Peptide Antagonist
93:PN:US7456252 SEQID:93 claimed sequence
L-Alanine, L-α-glutamyl-L-lysyl-L-prolyl-L-lysyl-L-valyl-L-α-glutamyl-L-alanyl-L-tyrosyl-L-lysyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-prolyl-
MBP 85-99

CAS:

444305-16-2

MF:

C70H114N18O21

MW:

1543.78

Product Categories:

Neurobiology
Neuroscience
Neural Proteins

Mol File:

444305-16-2.mol

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MBP (85-99) peptide antagonist trifluoroacetate salt Chemical Properties

Boiling point:: 1860.2±65.0 °C(Predicted)
Density: 1.299±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: H2O: >1mg/mL
form: lyophilized powder
pka: 3.70±0.10(Predicted)
Sequence: Glu-Lys-Pro-Lys-Val-Glu-Ala-Tyr-Lys-Ala-Ala-Ala-Ala-Pro-Ala

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Safety Information

WGK Germany: 3

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MBP (85-99) peptide antagonist trifluoroacetate salt Usage And Synthesis

Description

MBP (85-99) peptide antagonist, or J5, is a 15 amino acid peptide fragment designed on the binding motif of MBP 85-99 (myelin basic protein 85-99) to HLA-DR2 (human leukocyte antigen-DR2), which competes with and inhibits the binding of MBP (85-99) to HLA-DR2 and IL-2. MBP 85-99 is the the immunodominant epitope of MBP and a major candidate autoantigen in multiple sclerosis (MS), making this peptide a useful tool for MS research. p>

Biochem/physiol Actions

MBP (85-99) peptide antagonist inhibits binding of MBP 85-99 to HLA-DR2 and IL-2; tool for MS research. MBP (85-99) peptide antagonist inhibits the binding of MBP 85-99 to HLA-DR2 and IL-2 and is a tool for MS research. The peptide antagonist is a 15-mer peptide that competes with Myelin Basic Protein MBP (85-99), the immunodominant epitope of MBP and major candidate autoantigen in multiple sclerosis (MS).

References

[1] CASSANDRA E SMITH. Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005: 9595-9600. DOI:10.1073/pnas.0504131102.
[2] JOEL N H STERN. Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 5: 1620-1625. DOI:10.1073/pnas.0409022102.
[3] FRIDKIS-HARELI M. Design of peptide immunotherapies for MHC Class-II-associated autoimmune disorders.[J]. Clinical & Developmental Immunology, 2013, 2013: 826191. DOI:10.1155/2013/826191.

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Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Email: zhao.xu@njpeptide.com

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