Prolactin-Releasing Peptide (1-31) (human)
Prolactin-Releasing Peptide (1-31) (human) Basic information
- Product Name:
- Prolactin-Releasing Peptide (1-31) (human)
- Synonyms:
-
- H-Ser-Arg-Thr-His-Arg-His-Ser-Met-Glu-Ile-Arg-Thr-Pro-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Ala-Ser-Arg-Gly-Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2
- PrRP31 (huMan), Preprolactin (23-53) (huMan)
- Human PrRP-31
- CAS:
- 215510-22-8
- MF:
- C160H252N56O42S
- MW:
- 3664.12788
- Mol File:
- 215510-22-8.mol
Prolactin-Releasing Peptide (1-31) (human) Chemical Properties
- solubility
- Water: 1 mg/ml
- form
- A lyophilized powder
- color
- White to off-white
- Sequence
- Ser-Arg-Thr-His-Arg-His-Ser-Met-Glu-Ile-Arg-Thr-Pro-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Ala-Ser-Arg-Gly-Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2
Prolactin-Releasing Peptide (1-31) (human) Usage And Synthesis
Uses
Prolactin Releasing Peptide (1-31), human is a high affinity GPR10 ligand that cause the release of the prolactin. Prolactin Releasing Peptide (1-31) binds to GPR10 for human and rats with Ki values of 1.03 nM and 0.33 nM, respectively. Prolactin Releasing Peptide (1-31) can be used for the research of the hypothalamo-pituitary axis[1][2].
in vivo
Prolactin Releasing Peptide (1-31) (human) (ICV, 5 nM) increases plasma FSH, total plasma testosterone and significantly increased the release of LHRH from hypothalamic explants in vitro[2].
Prolactin Releasing Peptide (1-31) (human) (ICV, 100 nM) increases the hypothalanic peptides involved in the control of pituitary hormone release, vasoactive intestinal peptide (VIP) and galanin but had no effect on orexin A secretion[2].
References
[1] Langmead CJ, et al. Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor. Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor. DOI:10.1038/sj.bjp.0703617
[2] L J Seal, et al. Prolactin releasing peptide (PrRP) stimulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) via a hypothalamic mechanism in male rats. Endocrinology. 2000 May;141(5):1909-12. DOI:10.1210/endo.141.5.7528
Prolactin-Releasing Peptide (1-31) (human)Supplier
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Prolactin-Releasing Peptide (1-31) (human)(215510-22-8)Related Product Information
- Prolactin Releasing Peptide (12-31), human
- Prolactin-Releasing Peptide (12-31), rat
- PROLACTIN,HUMAN,RECOMBINANT
- Prolactin Releasing Peptide (1-31), HumanPrRP-31
- Prolactin, Mouse, Recombinant
- Prolactin, rat recombinant
- Prokineticin-2, Human, Recombinant
- H-THR-PRO-ASP-ILE-ASN-PRO-ALA-TRP-TYR-ALA-GLY-ARG-GLY-ILE-ARG-PRO-VAL-GLY-ARG-PHE-NH2
- H-SER-ARG-ALA-HIS-GLN-HIS-SER-MET-GLU-ILE-ARG-THR-PRO-ASP-ILE-ASN-PRO-ALA-TRP-TYR-ALA-GLY-ARG-GLY-ILE-ARG-PRO-VAL-GLY-ARG-PHE-NH2
- H-SER-ARG-ALA-HIS-GLN-HIS-SER-MET-GLU-THR-ARG-THR-PRO-ASP-ILE-ASN-PRO-ALA-TRP-TYR-THR-GLY-ARG-GLY-ILE-ARG-PRO-VAL-GLY-ARG-PHE-NH2