MANZAMINE A
MANZAMINE A Basic information
- Product Name:
- MANZAMINE A
- Synonyms:
-
- MANZAMINE A
- 1,13-Etheno-4,21a-methano-1H-azocino[1',2':1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol, 2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-, (1R,4S,9Z,13S,13aR,20aR,21aR)-
- Keramamine A
- CAS:
- 104196-68-1
- MF:
- C36H44N4O
- MW:
- 548.76
- Mol File:
- 104196-68-1.mol
MANZAMINE A Chemical Properties
- Melting point:
- ＞240(disassembly)
- Boiling point:
- 756.6±60.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- form
- Off white to yellow solid.
- pka
- 13.58±0.40(Predicted)
- color
- Off-White to Pale Yellow
- optical activity
- +5020 (CHCl3)
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
MANZAMINE A Usage And Synthesis
Description
Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis?in vivo2. Manzamine A displays neuritogenic activity3?and suppresses tau hyperphosphorylation in human neuroblastoma cell lines4.
Uses
Manzamine A is a β-Carboline alkaloid with anti-inflammatory.
Definition
ChEBI: An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).
in vivo
Manzamine A (50 and 100 mol/kg, p.o. or i.p.) inhibits the growth of the rodent malaria parasitePlasmodium berghei in infected mice[6].
Manzamine A (8 mg/kg, i.p., daily for 8 consecutive days) prolongs the survival of SW mice to 20 days[7].
| Animal Model: | Plasmodium berghei in infected mice[6] |
| Dosage: | 50 or 100 mol/kg |
| Administration: | Intraperitoneal injection (i.p.) or oral administration (p.o.) |
| Result: | Inhibited the growth of the rodent malaria parasite Plasmodium berghei. Prolonged the survival of highly parasitaemic mice. |
IC 50
Plasmodium; GSK-3β: 10.2 μM (IC50); CDK5: 1.5 μM (IC50); vacuolar ATPases; Malaria; HSV-1
storage
+4°C
References
[1] GEORGIOS KALLIFATIDIS. The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells.[J]. Marine Drugs, 2013, 11 9: 3500-3516. DOI:10.3390/md11093500
[2] KEISUKE EGUCHI . Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo[J]. Bioorganic & Medicinal Chemistry, 2013, 21 13: Pages 3831-3838. DOI:10.1016/j.bmc.2013.04.025
[3] BO ZHANG. Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. ingens (Thiele, 1899).[J]. Chemical & pharmaceutical bulletin, 2008, 56 6: 866-869. DOI:10.1248/cpb.56.866
[4] MARK HAMANN. Glycogen Synthase Kinase-3 (GSK-3) Inhibitory Activity and Structure–Activity Relationship (SAR) Studies of the Manzamine Alkaloids. Potential for Alzheimer’s Disease[J]. Journal of Natural Products , 2007, 70 9: 1397-1405. DOI:10.1021/np060092r
MANZAMINE ASupplier
- Tel
- 021-65675885 18964387627
- info@efebio.com
- Tel
- 028-028-85370565-229-229 18080489829
- 18080489829@163.com
- Tel
- 0755-85201366 18938635012
- sales@regentsciences.com
- Tel
- 400-9205774
- sales@glpbio.cn
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
MANZAMINE A(104196-68-1)Related Product Information
- OUABAIN OCTAHYDRATE
- AR-A014418
- SB216763
- Ethacrynic acid
- 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
- SB 415286
- 1-AZAKENPAULLONE
- KAHWEOL
- SEDANOLIDE
- S-[N-(3-PHENYLPROPYL)(THIOCARBAMOYL)]-L-CYSTEINE
- CAFESTOL
- 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE
- (R)-TERT-LEUCINOL
- 3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-OL
- 4-PYRIDIN-2-YL-BUTYLAMINE
- MANZAMINE A
- N,N-DIBUTYL-2-ETHYLHEXYLAMINE
- manzamine F