hydroxocobalamin monohydrochloride
hydroxocobalamin monohydrochloride Basic information
- Product Name:
- hydroxocobalamin monohydrochloride
- Synonyms:
-
- Einecs 261-772-4
- Cobinamide hydroxide dihydrogen phosphate (ester), inner salt 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole monohydrochloride
- hydroxocobalamin monohydrochloride
- Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3), monohydrochloride
- Cobinamide,Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3), hydrochloride (1:1)
- Vitamin B12a monohydrochloride
- Vitamin B12a hydrochloride >=96% (UV), >=96% (HPLC)
- Hydroxocobalain onohydrochloride
- CAS:
- 59461-30-2
- MF:
- C62H89ClCoN13O15P
- MW:
- 1381.83
- EINECS:
- 261-772-4
- Mol File:
- 59461-30-2.mol
hydroxocobalamin monohydrochloride Chemical Properties
- storage temp.
- 2-8°C
- solubility
- methanol: soluble10mg/mL at 20°C, clear, dark red
hydroxocobalamin monohydrochloride Usage And Synthesis
Biological Activity
Hydroxocobalamin monohydrochloride (Vitamin B12a monohydrochloride) is an injectable, natural vitamin B12 with a favorable adverse reaction profile that can be used as a dietary supplement for vitamin B12 deficiency, including pernicious anemia.
in vitro
The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide and hydroxocobalamin attenuates vascular responses to NO in vitro .
in vivo
Treatment with hydroxocobalamin before or after giving LPS attenuates LPS-induced hypotension and increases in plasma RNI and enhances LPS-induced urinary excretion of RNI. Hydroxocobalamin (20 mg/kg ip) given to Swiss-Webster mice 30 min before giving LPS (16 mg/kg ip) decreases the 24-hr mortality of LPS from 80 to 50% and the 36- and 96-hr mortality from 100 to 60% (hydroxocobalamin).
More than 60% of the mice administered 35 mg/kg (0.63 mmol/kg) of NaSH (LD90) survive (at 24 h) when hydroxocobalamin (0.25 mmol/kg) was given after NaSH administration whereas less than 15% of the mice survive without hydroxocobalamin. Hydroxocobalamin (50–100 μM) or cobalt (50–100 μM) also preventes hepatocyte cytotoxicity induced by NaSH (500 μM). Furthermore, adding hydroxocobalamin 60 min later than NaSH still shows some protective activity.
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