Product Identification

Product Name

Nimesulide

Synonyms

1-(Benzothiazol-2-yl)-1,3-dimethylurea
Aulin
Mesulid
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
N-(4-Nitro-2-phenoxy-phenyl)methanesulfonamide
Nimesulide

CAS

51803-78-2

Formula

C13H12N2O5S

Molecular Weight

308.31

EINECS

257-431-4

RTECS

PB0970000

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,6640

Beilstein/Gmelin

2421175

Beilstein Reference

6-13

Physical and Chemical Properties

Solubility in water

10 mg/L (20 C)

Melting Point

143 - 144

Boiling Point

442

Vapor Pressure

5E-8 (25 C)

Density

1.476 g/cm3

pKa/pKb

8.49 (pKa)

Heat Of Vaporization

69.9 kJ/mol

Usage

Treatment of hyperpyrexia related to respiratory infections.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.

Skin

In case of contact, immediately wash skin with soap and copious amounts of water.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed.

Hazards Identification

Inhalation

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause eye irritation.

Ingestion

May be harmful if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

50/53

EC Safety Phrase

60 61

UN (DOT)

3077

Exposure Controls/Personal Protection

Personal Protection

Protective gloves. Chemical safety goggles.

Respirators

Wear dust mask.

Exposure Effects

Avoid contact and inhalation.

Poison Class

4

Fire Fighting Measures

Flash Point

221

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Fire Potential

May burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

3077

Hazard Class

9

Packing Group

III