Product Identification

Product Name

Rutaecarpine

Synonyms

8,13-Dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
Rhetine
Rutaecarpine

CAS

84-26-4

Formula

C18H13N3O

Molecular Weight

287.32

Merck

12,8451

Physical and Chemical Properties

Appearance

White solid.

Solubility in water

26 mg/L (25 C)

Melting Point

259.5 - 260

Boiling Point

550

Vapor Pressure

3.8E-12 (25 C)

Density

1.45 g/cm3 (20 C)

pKa/pKb

8.62 (pKb)

Partition Coefficient

2.03

Heat Of Vaporization

83.01 kJ/mol

Usage

Inhibits platelet aggregation; vasoldilator.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of contact, immediately wash skin with soap and copious amounts of water. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Store at 2 - 8 C. Keep container tightly closed.

Hazards Identification

Inhalation

Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.

Skin

Causes irritation. May be harmful if absorbed through the skin.

Eyes

May cause irritation.

Ingestion

Toxic if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

25

EC Safety Phrase

45

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles. Protective clothing.

Respirators

Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N99 (US) or type P2 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator.

Exposure Effects

Target organs/systems: Cardiovascular system. Central nervous system. Blood.

Fire Fighting Measures

Flash Point

286

Fire Fighting

Extinguish with water spray, carbon dioxide, dry chemical powder or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

III