Rutaecarpine Chemical Properties

Melting point:

259.5-260°

Boiling point:

429.62°C (rough estimate)

Density 

1.2030 (rough estimate)

refractive index 

1.5855 (estimate)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO: 18 mg/mL clear yellow solution, soluble

form 

solid

pka

15.79±0.20(Predicted)

color 

white

Merck 

14,8298

InChIKey

ACVGWSKVRYFWRP-UHFFFAOYSA-N

CAS DataBase Reference

84-26-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

Risk Statements 

25-36/37/38

Safety Statements 

45-36-26

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

NM3454000

HS Code 

29339900

MSDS

• Language:English Provider:Rutaecarpine
• Language:English Provider:SigmaAldrich

Rutaecarpine Usage And Synthesis

Description

This alkaloid occurs with Evodiamine (q.v.) in the Chinese drug 'Wou-chou-yu' which is the dried fruit of Evodia rutaecarpa Benth. It crystallizes from boiling EtOH as colourless, or pale yellow, needles and is optically inactive. The acetyl derivative has m.p. 184-6°C and the benzoyl compound, m.p. 194°C. The alkaloid gives a yellow colour with concentrated H2S04 and is decomposed by KOH in boiling amyl alcohol yielding anthranilic acid and 3-{3-aminoethylindole- 2-O!carboxylic acid, CllH120 2N2, silky crystals, m.p. 257°C.
Pharmacologically, the alkaloid causes increased arterial pressure on injection.

Chemical Properties

Solid

Uses

Rutaecarpine is an indole alkaloid contained in the fruit of Evodiae fruits. It been shown to ameliorate bodyweight gain through orexigenic neuropeptides NPY and AgRP. It also playes a role in the treatment of high blood pressure

Definition

ChEBI: Rutecarpine is a member of beta-carbolines.

References

Asahina, Kashiwagi., J. Pharm. Chim., 14,54 (1916)
Asahina, Mayeda.,J. Pharm. Soc., Japan, No. 416 (1916)
Asahina, Fujita., ibid, 863 (1921)
Kermack, Perkin, Robinson.,J. Chem. Soc., 119,1615 (1921)
Asahina, Manske, Robinson., ibid, 1708 (1927)
Asahina, Irie, Ohta., J. Pharm. Soc., Japan, 48, 51 (1928)
Ohta., ibid, 60, 109 (1940)
Schopf, Steuer., Annalen, 558, 124 (1947)
Biosynthesis:
Yamazaki, Ikuta., Tetrahedron Lett., 3221 (1966)
Yamazakietal., ibid, 3317 (1967)
Pharmacology:
Raymond-Hamet., Cornpt. rend., 220, 749 (1945)

Rutaecarpine(84-26-4)Related Product Information

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