Basic information Introduction Efficacy and effect Pharmacological effects Safety Supplier Related
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Crocin

Basic information Introduction Efficacy and effect Pharmacological effects Safety Supplier Related

Crocin Basic information

Product Name:
Crocin
Synonyms:
  • saffron(natural)
  • ucopyranosyl)ester
  • Crocin ,98%
  • CrocinⅡ ,98%
  • Crocin ,96%
  • Crocin,Crocetin digentiobiose ester
  • Crocetin digentiobioside
  • Crocin 1
CAS:
42553-65-1
MF:
C44H64O24
MW:
976.97
EINECS:
255-881-6
Product Categories:
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
42553-65-1.mol
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Crocin Chemical Properties

Melting point:
186° (effervescence)
Boiling point:
1169.0±65.0 °C(Predicted)
Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly, Heated), Methanol (Very Slightly, Sonicated)
form 
Powder
pka
12.20±0.70(Predicted)
color 
Orange to Very Dark Purple
Merck 
14,2589
Stability:
Light Sensitive
InChIKey
OXNHRKGZZFWUQZ-QORFUXSJSA-N
LogP
-4.742 (est)
CAS DataBase Reference
42553-65-1
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
RTECS 
HL7380000
1-8-10
HS Code 
32129000
Hazardous Substances Data
42553-65-1(Hazardous Substances Data)

MSDS

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Crocin Usage And Synthesis

Introduction

Crocin (crocin) is also known as a-crocin and crocetin. It is a series of ester glycosides combining water-soluble carotenoids crocetin and different sugars. It is one of the main active ingredients of saffron, including crocin -1, crocin -2, crocin -3, crocin-4 and crocetin.It is centrally acting antihypertensive and can prevent atherosclerosis and be of antithrombosis, antiplatelet aggregation, and anti myocardial ischemia.

Efficacy and effect

The traditional medicine believes that the stigma croci can dredge and activate the collaterals, remove blood stasis, eradicate depression and relieve swelling and pain. It is mainly used for the treatment of anxiety depression, chest distention, irregular menstruation, postpartum haemorrhage and traumatic injury. The main effective components are crocetin and crocin, which has many pharmacological activities, such as being anti-inflammatory and analgesic, antitumor, antidepressant, hypoglycemic and lowering blood pressure. Because the water solution of stigma croci is bright yellow with sweet smell, it is often used as a food additive and high-grade edible pigment, but also can be used as high dye for silk, cotton and wool products. In recent years, pharmacological researches indicate that stigma croci has good control effect for a variety of diseases, including cancer, coronary heart disease, atherosclerosis and hyperlipidemia.

Pharmacological effects

Crocin has the effect of the anti-inflammation and treatment of soft tissue injury, gall liver protection, anti-tumor and other pharmacological effects. It is widely used in food, medicine, chemical industry and other industries. It is used in the treatment of patients with cardiovascular disease and fatty liver.with good medicinal value.

Description

Crocin/Gardenia Extract is a Gardenia extract that contains crocin I, II, and III, and crocetin, among other compounds.

Chemical Properties

Crocin is a reddish brown needle-like crystal. Slightly odor. Easily soluble in hot water, becomes the orange solution. Slightly soluble in anhydrous ethanol, ether, and other organic solvents. Insoluble in oil. The aqueous solution is weakly acidic or neutral transparent bright yellow, with a maximum absorption wavelength of 442nm. color is almost unaffected by pH value. Light and heat resistance is good in neutral or alkaline, and poor in acidic. Metal ion resistance (except iron, blackened by iron) is good. The coloring of protein is better than that of starch and is not affected by pH (pH4-10).

Uses

Crocin, is a natural carotenoid derived the flowers crocus and gardenia. Crocin has been shown to be a potent antioxidant. It has also been shown to have an antiproliferative action against cancer cells in vitro, and also possessing possible antidepressant properties.

Definition

ChEBI: Crocin-1 is a diester that is crocetin in which both of the carboxy groups have been converted to their gentiobiosyl esters. It is one of the water-soluble yellow-red pigments of saffron and is used as a spice for flavouring and colouring food. Note that in India, the term 'Crocin' is also used by GlaxoSmithKline as a brand-name for paracetamol. It has a role as an antioxidant, a food colouring, a plant metabolite and a histological dye. It is a diester, a disaccharide derivative and a diterpenoid. It is functionally related to a beta-D-gentiobiosyl crocetin and a gentiobiose.

General Description

Crocin (CR) is a water-soluble carotenoid found in Gardenia jasmi-noides Ellis and Crocus sativus (saffron). It has two D-gentiobioside glycosyl esters in its structure. CR is one of the major bioactive compounds of saffron contributing to its red color. A highly unsaturared diterpene dicarboxylic acid ester found in saffron.

Biochem/physiol Actions

Crocin alleviates some ethanol-induced impairments of learning and prevents ethanol-induced inhibition of hippocampal long-term potentiation (LTP), a form of activity-dependent synaptic plasticity that may underly learning and memory. Related CNS effects are specific to the digentiobiose ester; crocetin glucose gentiobiose ester is half as potent, and the diglucose ester has no effect at all.

Crocin Preparation Products And Raw materials

Raw materials

CrocinSupplier

Shaanxi Pioneer Biotech Co.,Ltd Gold
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029-029-84385017-8001-8001 18220517932
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sales5@pioneerbiotech.com
Shanghai Moqi Biological Technology Co., LTD Gold
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021-38218169 13341702378
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190129269@qq.com
Hubei Hongfuda Biotechnology Co., Ltd. Gold
Tel
191-07255884 19107255884
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259506217@qq.com
Chengdu Nakeli Biotechnology Co., Ltd. Gold
Tel
028-61983833 19138982515
Email
3265827856@qq.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com