Product Identification

Product Name

4-Ethoxyaniline

Synonyms

2,3-Dihydro-6-nitro-1H-indole
4-Aminophenetole
4-Ethoxyaniline
4-Ethoxybenzenamine
6-Nitro-2,3-dihydro-1H-indole
Benzenamine, 4-ethoxy-
p-Aminophenyl ethyl ether

CAS

156-43-4

CAS

19727-83-4

Formula

C8H11NO

Formula

C8H8N2O2

Molecular Weight

164.16

Molecular Weight

137.18

EINECS

205-855-5

EINECS

243-257-6

RTECS

NM1950000

RTECS

SI6465500

RTECS Class

Drug; Mutagen; Primary Irritant

RTECS Class

Mutagen

Merck

12,7373

Beilstein/Gmelin

606666

Beilstein/Gmelin

156434

Beilstein Reference

4-13-00-01017

Beilstein Reference

4-20-00-02904

EC Index Number

612-039-00-6

EC Class

Toxic; Danger of cumulative effects

Physical and Chemical Properties

Appearance

Colorless to dark red liquid.

Appearance

Red crystals.

Solubility in water

Insoluble

Solubility in water

5-10 mg/ml

Melting Point

66 - 67

Melting Point

4

Boiling Point

254

Vapor Pressure

0.02 (25 C)

Density

1.0613 g/cm3 (15 C)

pKa/pKb

10.93 (pKb)

pKa/pKb

8.74 (pKb)

Partition Coefficient

1.28

Heat Of Vaporization

49.1 kJ/mol

Usage

Production of acetophenetidine, phenocoll, dulcin, dyes.

Vapor Density

4.73

Refractive Index

1.5572 (15.9 C)

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Inhalation

May cause respiratory tract irritation.

Skin

May cause skin irritation.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

May cause eye irritation.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container.

Storage

Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed. Store protected from light and air.

Handling

Wash thoroughly after handling. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Store protected from light. Store protected from air.

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.

Hazards Identification

Ingestion

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

Inhalation

May cause respiratory tract irritation. Effects of inhalation may be delayed.

Skin

Causes mild skin irritation. May be absorbed through the skin. Effects of contact may be delayed.

Eyes

Causes moderate eye irritation.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed.

Hazards

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

EC Risk Phrase

R 20/21/22 33

EC Risk Phrase

R 23/24/25 33

EC Safety Phrase

S 22 36/37

EC Safety Phrase

S 28 36/37 45

UN (DOT)

2311

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Personal Protection

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

There is a danger of cumulative effects.

Fire Fighting Measures

Flash Point

115

Autoignition

460

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Do NOT get water inside containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Fire Potential

This compound is combustible.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Provide ventilation.

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Disposal Code

9

Incompatibilities

Acids - acid chlorides - acid anhydrides - chloroformates - strong oxidizing agents - light - air.

Stability

No data.

Stability

Stable under normal temperatures and pressures. Air sensitive Light sensitive.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Decomposition

Carbon monoxide, oxides of nitrogen, carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2311

UN Number

2811

Hazard Class

6.1

Packing Group

III

HS Code

2922 22 00