Product Identification

Product Name

4-Methylphenyl isocyanate

Synonyms

1-Isocyanato-4-methylbenzene
4-Isocyanatotoluene
4-Methylphenyl isocyanate
Isocyanic acid, p-tolyl ester
p-Isocyanatotoluene
p-Methylphenyl isocyanate

CAS

622-58-2

Formula

C8H7NO

Molecular Weight

133.15

EINECS

210-743-4

RTECS

DA3681666

RTECS Class

Other

Beilstein/Gmelin

4094771

Physical and Chemical Properties

Appearance

Light brown liquid.

Solubility in water

Insoluble

Boiling Point

193 - 195

Vapor Pressure

0.54 (25 C)

Density

1.056 g/cm3 (20 C)

Partition Coefficient

3.04

Heat Of Vaporization

42.7 kJ/mol

Refractive Index

1.5313 (20 C)

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Animals exposed to 0.48 mg/l, the lowest dose tested, died in sixteen days.

Skin

May cause skin irritation. The toxicological properties of this material have not been fully investigated.

Eyes

May cause eye irritation. The toxicological properties of this material have not been fully investigated.

Hazards

Vapors form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff.

EC Risk Phrase

R 23 22 36/37/38 42

EC Safety Phrase

S 23 26 36/37/39 45

UN (DOT)

2206

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Flash Point

64

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation.

Stability and Reactivity

Incompatibilities

Oxidizing agents.

Stability

Stable under normal temperatures and pressures.

Decomposition

Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Combustion Products

Fire will produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2206

Hazard Class

6.1

Packing Group

II; III