Product Identification

Product Name

1-Isopropylamino-3-(naphthalen-1-yloxy)-propan-2-ol

Synonyms

1-(Isopropylamino)-3-(1-Naphthyloxy)-2-propanol
1-Propanolol
Avlocardyl
Euprovasin
Inderal
Racemic propranolol

CAS

525-66-6

Formula

C16H21NO2

Molecular Weight

259.35000000000002

EINECS

208-378-0

RTECS

UB7500000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,8025

Beilstein/Gmelin

987417

Physical and Chemical Properties

Appearance

Crystals from cyclohexane.

Solubility in water

Slightly soluble

Melting Point

164 - 165

Boiling Point

435

Vapor Pressure

2E-8 (25 C)

pKa/pKb

4.86 (pKb)

Partition Coefficient

3.65

Heat Of Vaporization

72.8 kJ/mol

Usage

Medication (vet).

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Increased airway resistance, wheezing, pulmonary edema, cyanosis, respiratory depression may develop. In severe cases respiratory arrest may occur.

Eyes

Diplopia and eye irritation may develop with therapeutic use. Mydriasis has been reported overdose.

Ingestion

Nausea and vomiting may be noted. Mesenteric ischemia has been reported as a sequelae of overdose.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

Low heart rate and abnormally low blood pressure are common. Respiratory depression may occur with severe poisoning. fatigue, sleepiness, headache, sedation and confusion may develop with therapeutic use. CNS depression, coma and seizures may develop in overdose.

Fire Fighting Measures

Flash Point

217

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

It is stable to heat, unstable to light.

Incompatibilities

Strong oxidizing agents.