Product Identification

Product Name

14,15b-Epoxy-3b,5a,16b-trihydroxy-5b,20(22)-bufadienolide 16-acetate

Synonyms

14,15-Epoxy-14H-cyclopenta[a]phenanthrene, bufa-20,22-dienolide deriv.
5-b-Bufa-20,22-dienolide, 14,15-b-epoxy-3-b,5,16-b-trihydroxy, 16-acetate
Bufa-20,22-dienolide, 16- (acetyloxy)-14,15-epoxy-3,5-dihydroxy-, (3.beta.,5.beta.,15.beta.,16.beta.)-

CAS

1108-68-5

Formula

C26H34O7

Molecular Weight

458.55

RTECS

EI2991000

Merck

12,2367

Physical and Chemical Properties

Solubility in water

.73

Melting Point

259 - 262

Boiling Point

627

Vapor Pressure

2.3E-18 (25 C)

Density

1.34 kJ/mol

pKa/pKb

14.67 (pKa)

Partition Coefficient

.87

Heat Of Vaporization

106/4 kJ/mol

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of contact, immediately wash skin with soap and copious amounts of water. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Store at 2 - 8 C.

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles. Protective clothing.

Respirators

Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator.

Exposure Effects

May be fatal if inhaled, swallowed, or absorbed through skin. Toad venoms are cardioactive and can cause death by disturbing the normal heart rhythm. The mucous membrane that lines the mouth is a means of introducing the venom into the bloodstream. (Venomous Animals and Their Venoms, vol. II: Bucherl, W. Editor).

Fire Fighting Measures

Flash Point

210

Fire Fighting

Extinguish with water spray, carbon dioxide, dry chemical powder or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Carefully sweep up and remove. Place in appropriate container. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Incompatibilities

Moisture.

Stability

Stable at normal temperatures and pressures.

Decomposition

Oxides of carbon.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

I

Hazards Identification

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

26/27/28

EC Safety Phrase

22 36/37/39 45

UN (DOT)

2811