Product Identification

Product Name

(S)-(+)-1-Amino-2-propanol

Synonyms

Isopropanolamine
Threamine

CAS

2799-17-9

Formula

C3H9NO

Molecular Weight

75.11

EINECS

220-533-4

RTECS

UA5775000

Beilstein/Gmelin

1718868

Beilstein Reference

4-04-00-01665

EC Index Number

603-082-00-1

EC Class

corrosive

Physical and Chemical Properties

Appearance

Colorless liquid.

Solubility in water

Very soluble

Melting Point

-2

Boiling Point

160

Vapor Pressure

0.86 (25 C)

Density

0.960 g/cm3 (20 C)

pKa/pKb

4.82 (pKb)

Usage

An intermediate in the synthesis of a variety of pharmaceutical drugs and is the very basic building block of the opioid, methadone.

Refractive Index

1.44 (20 C)

First Aid Measures

Ingestion

Seek medical assistance.

Inhalation

Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.

Skin

Remove and isolate contaminated clothing and shoes. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.

Eyes

Immediately flush with running water for at least 20 minutes.

Hazards Identification

Ingestion

See Inhalation.

Inhalation

TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.

Skin

Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.

Eyes

See Inhalation.

Hazards

Contact with metals may evolve flammable hydrogen gas.

EC Risk Phrase

R 34

EC Safety Phrase

S 23 26 36 45

UN (DOT)

3259

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate protective gloves, clothing and goggles.

Respirators

Wear positive pressure self-contained breathing apparatus (SCBA).

Poison Class

4 (Substances and products that must be considered harmful)

Fire Fighting Measures

Flash Point

71

Autoignition

335

Fire Fighting

Extinguish using agent most appropriate for surrounding fire.

Fire Potential

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Accidental Release Measures

Small spills/leaks

ELIMINATE all ignition sources. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.

Stability and Reactivity

Disposal Code

3

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

3259

HS Code

2922 19 80