Product Identification

Product Name

Terazosin

Synonyms

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine
Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-

Vasomet

CAS

63590-64-7

Formula

C19H25N5O4

Molecular Weight

387.44

RTECS

TK8044925

Merck

12,9297

Physical and Chemical Properties

Appearance

White to off-white powder.

Solubility in water

4 g/L (25 C)

Melting Point

273

Boiling Point

665

Vapor Pressure

1.6E-17 (25 C)

Density

1.33 g/cm3 (20 C)

pKa/pKb

7.55 (pKb)

Partition Coefficient

-.96

Heat Of Vaporization

97.72 kJ/mol

Usage

1-Adrenoceptor antagonist.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of contact, immediately wash skin with soap and copious amounts of water. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed. Store in a cool dry place.

Hazards Identification

Inhalation

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause irritation.

Ingestion

Harmful if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

22

EC Safety Phrase

26

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles. Protective clothing.

Exposure Effects

Target organs or systems: Cardiovascular system. Central nervous system. Dizziness and other signs of hypotension, facial flushing, and tachycardia. Exposure may cause nausea and vomiting.

Fire Fighting Measures

Flash Point

355

Fire Fighting

Extinguish with water spray, carbon dioxide, dry chemical powder or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides.