Product Identification

Product Name

2-Methylbenzene-1-sulfonamide

Synonyms

2-Methylbenzenesulfonamide
o-Methylbenzenesulfonamide
Saniticizer 9
Toluene-2-sulfonamide

CAS

88-19-7

Formula

C7H9NO2S

Molecular Weight

171.23

EINECS

201-808-8

RTECS

XT4900000

RTECS Class

Tumorigen; Mutagen; Reproductive Effector; Primary Irritant

Beilstein/Gmelin

1102362

Beilstein Reference

4-11-00-00229

Physical and Chemical Properties

Appearance

Octahedral crystals from alc, prisms from water.

Solubility in water

Slightly soluble

Melting Point

155 - 156

Boiling Point

330

Vapor Pressure

0.00017 (25 C)

pKa/pKb

10.17 (pKa)

Partition Coefficient

.84

Heat Of Vaporization

57.3 kJ/mol

Usage

Starting material for preparation of saccharin. Ortho- & para-toluenesulfonamide mixt is used as a reactive plasticizer.

First Aid Measures

Ingestion

The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.

Inhalation

Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Skin

Various dermatological reactions, including rash, pruritus, erythema nodosum, and quite severe and often fatal erythema multiforme of the stevens-johnson type have been reported. This serious reaction has been reported even with the use of ophthalmic preparations. Rashes and fever appear ten days after initiation of therapy and reoccur immediately upon additional courses of the therapy.

Ingestion

Nausea and vomiting are likely to occur.

EC Risk Phrase

R 40 36/37/38

EC Safety Phrase

S 26 36/37/39

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

headache, depression, and hallucinations have been reported with therapeutic use of sulfonamides. Coma and seizures were reported following a large overdose of sulfasalazine in one patient. Tremor occurred in one patient following a fixed-dose combination of trimethoprim/sulfamethoxazole.

Poison Class

2

Fire Fighting Measures

Flash Point

178

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.