Product Identification

Product Name

3,5-Di(trifluoromethyl)aniline

Synonyms

3,5-Bis(trifluoromethyl)aniline
3,5-Bis(trifluoromethyl)benzenamine
a,a,a,a',a',a'-Hexafluoro-3,5-xylidine

CAS

328-74-5

Formula

C8H5F6N

Molecular Weight

229.13

EINECS

206-335-0

RTECS

ZE9800000

RTECS Class

Other

Beilstein/Gmelin

654318

Beilstein Reference

3-12-00-02498

EC Class

irritant

Physical and Chemical Properties

Appearance

Clear yellow liquid.

Solubility in water

Insoluble

Melting Point

3

Boiling Point

176

Vapor Pressure

1.1 (25 C)

Density

1.4753 g/cm3 (20 C)

pKa/pKb

11.85 (pKb)

Partition Coefficient

4.04

Heat Of Vaporization

41.2 kJ/mol

Vapor Density

7.9

Refractive Index

1.435 (20 C)

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Hazards Identification

Inhalation

Causes respiratory tract irritation. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. Can produce delayed pulmonary edema. Inhalation at high concentrations may cause CNS depression and asphixiation. May cause headache and dizziness.

Skin

Causes skin irritation. May cause dermatitis. May cause cyanosis of the extremities.

Eyes

Causes eye irritation. May cause chemical conjunctivitis and corneal damage.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May form methemoglobin which in sufficient concentration causes cyanosis. Causes headache and dizziness and possible narcotic effect.

Hazards

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

EC Risk Phrase

R 23/24/25 33 36/38

EC Safety Phrase

S 26 28 36/37/39 45

UN (DOT)

2810

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Effects may be delayed.

Fire Fighting Measures

Flash Point

83

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Extinguishing media: Use water spray to cool fire-exposed containers. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

Combustible material: may burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Use a spark-proof tool. Provide ventilation.

Stability and Reactivity

Stability

Stable at room temperature in closed containers under normal storage and handling conditions.

Incompatibilities

Strong oxidizing agents, strong acids.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride, fluoride fumes.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2810

Hazard Class

6.1

Packing Group

I; II; III

HS Code

2921 49 10