3,5-Bis(trifluoromethyl)aniline Chemical Properties

Melting point:

168.2-169.2 °C

Boiling point:

85 °C15 mm Hg(lit.)

Density 

1.467 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.434(lit.)

Flash point:

182 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Liquid

pka

2.15±0.10(Predicted)

Specific Gravity

1.473

color 

Clear light yellow to yellow-brown

Water Solubility 

Not miscible in water.

BRN 

654318

InChIKey

CDIDGWDGQGVCIB-UHFFFAOYSA-N

CAS DataBase Reference

328-74-5(CAS DataBase Reference)

NIST Chemistry Reference

Benzenamine, 3,5-bis(trifluoromethyl)-(328-74-5)

EPA Substance Registry System

Benzenamine, 3,5-bis(trifluoromethyl)- (328-74-5)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

33-36/37/38-20/21/22

Safety Statements 

26-36/37/39-36

RIDADR 

2810

WGK Germany 

3

RTECS 

ZE9800000

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29214910

MSDS

• Language:English Provider:3,5-Di(trifluoromethyl)aniline
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3,5-Bis(trifluoromethyl)aniline Usage And Synthesis

Chemical Properties

clear light yellow to yellow-brown liquid

Uses

3,5-Bis(trifluoromethyl)aniline was found to be a highly efficient monodentate transient directing group (MonoTDG) for the palladium-catalyzed direct dehydrogenative cross-coupling of benzaldehydes with arenes.

Synthesis

The synthesis of 3,5-Bis(trifluoromethyl)aniline is as follows is as follows：Put 259g (1mol) 3,5-Bis(trifluoromethyl)nitrobenzeneand 500g ethyl acetate into a 1L autoclave, add 5g palladium-carbon as a catalyst, raise the temperature to 60℃, then pass the hydrogen pressure to 2MPa, keep the temperature and react for 20 hours, then cooling, filtration, concentration, and distillation to obtain 3,5-Bis(trifluoromethyl)aniline with a purity of 98.5% and a yield of 87%.

3,5-Bis(trifluoromethyl)aniline(328-74-5)Related Product Information

• 3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE
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• N1-methyl-3,5-di(trifluoromethyl)aniline